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CHEBI:235525 - zacopride
| ChEBI ID | CHEBI:235525 |
| ChEBI Name | zacopride |
| Stars | |
| Definition | A racemate composed of equimolar amounts of (R)- and (S)-zacopride. It is a selective IK1 channel agonist that can suppress triggered arrhythmias in rats. |
| Last Modified | 1 October 2025 |
| Submitter | Adnan |
| Formula | C15H20ClN3O2 |
| Net Charge | 0 |
| Average Mass | 309.797 |
| Monoisotopic Mass | 309.12440 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. |
| Applications: | anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. cardioprotective agent Any protective agent that is able to prevent damage to the heart. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. nootropic agent Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| zacopride (CHEBI:235525) has part (R)-zacopride (CHEBI:235526) |
| zacopride (CHEBI:235525) has part (S)-zacopride (CHEBI:235527) |
| zacopride (CHEBI:235525) has role anti-arrhythmia drug (CHEBI:38070) |
| zacopride (CHEBI:235525) has role antidepressant (CHEBI:35469) |
| zacopride (CHEBI:235525) has role antiemetic (CHEBI:50919) |
| zacopride (CHEBI:235525) has role anxiolytic drug (CHEBI:35474) |
| zacopride (CHEBI:235525) has role cardioprotective agent (CHEBI:77307) |
| zacopride (CHEBI:235525) has role nootropic agent (CHEBI:66980) |
| zacopride (CHEBI:235525) has role serotonergic agonist (CHEBI:35941) |
| zacopride (CHEBI:235525) has role serotonergic antagonist (CHEBI:48279) |
| zacopride (CHEBI:235525) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| 4-amino-N-[(3RS)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2-methoxybenzamide |
| INNs | Source |
|---|---|
| zacopride | WHO MedNet |
| zacopride | WHO MedNet |
| zacoprida | WHO MedNet |
| zacopridum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (RS)-zacopride | ChEBI |
| RS-zacopride | ChEBI |
| racemic zacopride | ChEBI |
| rac-zacopride | ChEBI |
| (±)-zacopride | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| Zacopride | Wikipedia |
| HMDB0259981 | HMDB |
| LSM-1715 | LINCS |
| Registry Numbers | Sources |
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| CAS:90182-92-6 | ChEBI |
| Citations |
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