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CHEBI:235513 - Wnt-C59

ChEBI IDCHEBI:235513
ChEBI NameWnt-C59
Stars
DefinitionA secondary carboxamide resulting from the formal condensation of the amino group of 4-(pyridin-3-yl)aniline with the carboxy group of [4-(2-methylpyridin-4-yl)phenyl]acetic acid. It is a highly potent inhibitor of porcupine (IC50 = 74 pM), a member of the membrane-bound O-acyltransferase family.
Last Modified25 September 2025
SubmitterAdnan
DownloadsMolfile
FormulaC25H21N3O
Net Charge0
Average Mass379.463
Monoisotopic Mass379.16846
SMILESCc1cc(-c2ccc(CC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1
InChIInChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChIKeyKHZOJCQBHJUJFY-UHFFFAOYSA-N
Roles Classification
Biological Role:
Wnt signalling inhibitor  A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
Applications:
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
Wnt-C59 (CHEBI:235513) has role anti-inflammatory agent (CHEBI:67079)
Wnt-C59 (CHEBI:235513) has role antineoplastic agent (CHEBI:35610)
Wnt-C59 (CHEBI:235513) has role Wnt signalling inhibitor (CHEBI:78031)
Wnt-C59 (CHEBI:235513) is a benzamides (CHEBI:22702)
Wnt-C59 (CHEBI:235513) is a methylpyridines (CHEBI:25340)
Wnt-C59 (CHEBI:235513) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide
Synonyms  Source
4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamideChEBI
C59ChEBI
2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamideChEBI
Manual XrefsDatabases
HMDB0259900HMDB
Registry NumbersSources
CAS:1243243-89-1ChEBI
Citations