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CHEBI:234514 - dorzagliatin

ChEBI IDCHEBI:234514
ChEBI Namedorzagliatin
Stars
DefinitionA secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methylpentanoic acid with the amino group of (2R)-3-(3-amino-1H-pyrrol-1-yl)propane-1,2-diol. It is an allosteric glucokinase activator developed by Hua Medicine for the treatment of type 1 and 2 diabetes mellitus , and diabetic kidney disease.
Last Modified26 June 2025
Submitterdoughowe
DownloadsMolfile
FormulaC22H27ClN4O5
Net Charge0
Average Mass462.934
Monoisotopic Mass462.16700
SMILESCC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H](O)CO)n1)N1CC(Oc2ccccc2Cl)=CC1=O
InChIInChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1
InChIKeyHMUMWSORCUWQJO-QAPCUYQASA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
enzyme activator  An activator of an enzyme-catalysed reaction.
Application:
hypoglycemic agent  A drug which lowers the blood glucose level.
ChEBI Ontology
Outgoing Relation(s)
dorzagliatin (CHEBI:234514) has role enzyme activator (CHEBI:195252)
dorzagliatin (CHEBI:234514) has role hypoglycemic agent (CHEBI:35526)
dorzagliatin (CHEBI:234514) is a aromatic ether (CHEBI:35618)
dorzagliatin (CHEBI:234514) is a diol (CHEBI:23824)
dorzagliatin (CHEBI:234514) is a enone (CHEBI:51689)
dorzagliatin (CHEBI:234514) is a monochlorobenzenes (CHEBI:83403)
dorzagliatin (CHEBI:234514) is a primary alcohol (CHEBI:15734)
dorzagliatin (CHEBI:234514) is a pyrazoles (CHEBI:26410)
dorzagliatin (CHEBI:234514) is a pyrroline (CHEBI:23763)
dorzagliatin (CHEBI:234514) is a secondary alcohol (CHEBI:35681)
dorzagliatin (CHEBI:234514) is a secondary carboxamide (CHEBI:140325)
dorzagliatin (CHEBI:234514) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
INNs  Source
dorzagliatineWHO MedNet
dorzagliatinumWHO MedNet
dorzagliatinaWHO MedNet
dorzagliatinWHO MedNet
Synonyms  Source
HMS5552ChEBI
HMS 5552ChEBI
HMS-5552ChEBI
Brand Name  Source
HuaTangNingChEBI
Manual XrefsDatabases
DB15123DrugBank
D11342KEGG DRUG
DorzagliatinWikipedia
Registry NumbersSources
CAS:1191995-00-2DrugBank
Citations