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CHEBI:234392 - BRD4884

ChEBI IDCHEBI:234392
ChEBI NameBRD4884
Stars
DefinitionA secondary carboxamide resulting from the formal condensation of the carboxy group of oxane-4-carboxylic acid with the 3-amino group of 4'-fluoro[1,1'-biphenyl]-3,4-diamine. It is a HDAC inhibitor (IC50 = 29 nM, 62 nM, and 1.09 μM for HDAC1, HDAC2, and HDAC3, respectively) and has shown to enhance cognition in mouse models.
Last Modified12 June 2025
Submitteraxiao
DownloadsMolfile
FormulaC18H19FN2O2
Net Charge0
Average Mass314.360
Monoisotopic Mass314.14306
SMILESNc1ccc(-c2ccc(F)cc2)cc1NC(=O)C1CCOCC1
InChIInChI=1S/C18H19FN2O2/c19-15-4-1-12(2-5-15)14-3-6-16(20)17(11-14)21-18(22)13-7-9-23-10-8-13/h1-6,11,13H,7-10,20H2,(H,21,22)
InChIKeyZFCDNONWGMYBHA-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 3.5.1.98 (histone deacetylase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Application:
nootropic agent  Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
ChEBI Ontology
Outgoing Relation(s)
BRD4884 (CHEBI:234392) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
BRD4884 (CHEBI:234392) has role nootropic agent (CHEBI:66980)
BRD4884 (CHEBI:234392) is a biaryl (CHEBI:64459)
BRD4884 (CHEBI:234392) is a monofluorobenzenes (CHEBI:83575)
BRD4884 (CHEBI:234392) is a oxanes (CHEBI:46942)
BRD4884 (CHEBI:234392) is a secondary carboxamide (CHEBI:140325)
BRD4884 (CHEBI:234392) is a substituted aniline (CHEBI:48975)
IUPAC Name 
N-(4-amino-4'-fluoro[biphenyl]-3-yl)tetrahydro-2H-pyran-4-carboxamide
Synonyms  Source
BRD 4884SUBMITTER
BRD-4884SUBMITTER
N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamideIUPAC
N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)tetrahydro-2H-pyran-4-carboxamideChEBI
Manual XrefsDatabases
IWXPDBeChem
Registry NumbersSources
CAS:1404559-91-6SUBMITTER
Citations