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CHEBI:234356 - GSK-923295

ChEBI IDCHEBI:234356
ChEBI NameGSK-923295
Stars
DefinitionAn imidazopyridine that is imidazo[1,2-a]pyridine substituted by 4-{(2S)-2-[3-chloro-4-(propan-2-yloxy)benzamido]-3-[(N,N-dimethylglycyl)amino]propyl}phenyl, and (1S)-1-hydroxyethyl groups at positions 2 and 8, respectively. It is an allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity (Ki = 3.2 nM and 1.6 nM for human and canine CENP-E motordomains, respectively).
Last Modified19 June 2025
Submitteraxiao
DownloadsMolfile
FormulaC32H38ClN5O4
Net Charge0
Average Mass592.140
Monoisotopic Mass591.26123
SMILESCC(C)Oc1ccc(C(=O)N[C@H](CNC(=O)CN(C)C)Cc2ccc(-c3cn4cccc([C@H](C)O)c4n3)cc2)cc1Cl
InChIInChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
InChIKeyWHMXDBPHBVLYRC-OFVILXPXSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
antimitotic  Any compound that inhibits cell division (mitosis).
centromere protein E inhibitor  Any inhibitor of centromere protein E.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
GSK-923295 (CHEBI:234356) has role antimitotic (CHEBI:64911)
GSK-923295 (CHEBI:234356) has role antineoplastic agent (CHEBI:35610)
GSK-923295 (CHEBI:234356) has role centromere protein E inhibitor (CHEBI:234476)
GSK-923295 (CHEBI:234356) is a aromatic ether (CHEBI:35618)
GSK-923295 (CHEBI:234356) is a benzamides (CHEBI:22702)
GSK-923295 (CHEBI:234356) is a imidazopyridine (CHEBI:46908)
GSK-923295 (CHEBI:234356) is a monochlorobenzenes (CHEBI:83403)
GSK-923295 (CHEBI:234356) is a secondary alcohol (CHEBI:35681)
GSK-923295 (CHEBI:234356) is a secondary carboxamide (CHEBI:140325)
GSK-923295 (CHEBI:234356) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
3-chloro-N-[(2S)-1-[(N,N-dimethylglycyl)amino]-3-(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)propan-2-yl]-4-(propan-2-yloxy)benzamide
Synonyms  Source
GSK 923295ChEBI
GSK923295ChEBI
GSK923295AChEBI
GSK 923295AChEBI
GSK-923295AChEBI
GSK295ChEBI
Manual XrefsDatabases
DB06097DrugBank
LSM-45692LINCS
WO2010102157Patent
Registry NumbersSources
CAS:1088965-37-0SUBMITTER
Citations