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CHEBI:234355 - TRULI

ChEBI IDCHEBI:234355
ChEBI NameTRULI
Stars
DefinitionA pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine substituted by a N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)carboxamide group at position 3. It is a potent and ATP-competitive inhibitor of LATS1 and LATS2 kinases, and a YAP signaling activator.
Last Modified19 June 2025
Submitteraxiao
DownloadsMolfile
FormulaC18H14N4OS
Net Charge0
Average Mass334.404
Monoisotopic Mass334.08883
SMILESO=C(N=c1sccn1Cc1ccccc1)c1cnc2ncccc12
InChIInChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
InChIKeyVTXBMVZVPUSAJF-UHFFFAOYSA-N
Roles Classification
Biological Role:
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
ChEBI Ontology
Outgoing Relation(s)
TRULI (CHEBI:234355) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
TRULI (CHEBI:234355) is a 1,3-thiazoles (CHEBI:38418)
TRULI (CHEBI:234355) is a benzenes (CHEBI:22712)
TRULI (CHEBI:234355) is a enamide (CHEBI:51751)
TRULI (CHEBI:234355) is a pyrrolopyridine (CHEBI:46771)
IUPAC Name 
N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
Synonyms  Source
Lats-IN-1SUBMITTER
LATS inhibitor 1ChEBI
N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamideChEBI
The Rockefeller University Lats InhibitorChEBI
Registry NumbersSources
CAS:1424635-83-5SUBMITTER
Citations