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CHEBI:234329 - AZD3965

ChEBI IDCHEBI:234329
ChEBI NameAZD3965
Stars
DefinitionA thienopyrimidine that is thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione substituted by isopropyl, methyl, (4S)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl, and [5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl groups at positions 1, 3, 5, and 6, respectively. It is an inhibitor of monocarboxylate transporter 1 (Ki = 1.6 nM), and was previously in phase I clinical trials for the treatment of lymphomas and solid tumours.
Last Modified20 June 2025
Submitterdoughowe
DownloadsMolfile
FormulaC21H24F3N5O5S
Net Charge0
Average Mass515.514
Monoisotopic Mass515.14502
SMILESCc1nnc(C(F)(F)F)c1Cc1sc2c(c1C(=O)N1C[C@](C)(O)CO1)c(=O)n(C)c(=O)n2C(C)C
InChIInChI=1S/C21H24F3N5O5S/c1-9(2)29-18-14(16(30)27(5)19(29)32)13(17(31)28-7-20(4,33)8-34-28)12(35-18)6-11-10(3)25-26-15(11)21(22,23)24/h9,33H,6-8H2,1-5H3,(H,25,26)/t20-/m0/s1
InChIKeyPRNXOFBDXNTIFG-FQEVSTJZSA-N
Roles Classification
Biological Role:
monocarboxylate transporter 1 inhibitor  Any compound that inhibits the action of monocarboxylate transporter 1.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
AZD3965 (CHEBI:234329) has role antineoplastic agent (CHEBI:35610)
AZD3965 (CHEBI:234329) has role monocarboxylate transporter 1 inhibitor (CHEBI:234483)
AZD3965 (CHEBI:234329) is a organofluorine compound (CHEBI:37143)
AZD3965 (CHEBI:234329) is a oxazolidines (CHEBI:38329)
AZD3965 (CHEBI:234329) is a pyrazoles (CHEBI:26410)
AZD3965 (CHEBI:234329) is a tertiary carboxamide (CHEBI:140326)
AZD3965 (CHEBI:234329) is a thienopyrimidine (CHEBI:143212)
IUPAC Name 
5-{[(4S)-4-hydroxy-4-methyl-1,2-oxazolidin-2-yl]carbonyl}-3-methyl-6-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-1-(propan-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Synonyms  Source
5-[(4S)-4-hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-3-methyl-6-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-1-(propan-2-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dioneIUPAC
AZD-3965ChEBI
AZD 3965ChEBI
Registry NumbersSources
CAS:1448671-31-5ChEBI
Citations