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CHEBI:234245 - DADLE
| Formula | C29H39N5O7 |
| Net Charge | 0 |
| Average Mass | 569.659 |
| Monoisotopic Mass | 569.28495 |
| SMILES | CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O |
| InChI | InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1 |
| InChIKey | ZHUJMSMQIPIPTF-IBURTVSXSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | antinociceptive agent Any agent that inhibits nociception. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. mu-opioid receptor agonist A compound that exhibits agonist activity at the μ-opioid receptor. autophagy inducer Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). delta-opioid receptor agonist A compound that exhibits agonist activity at the δ-opioid receptor. |
| Applications: | antinociceptive agent Any agent that inhibits nociception. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. mu-opioid receptor agonist A compound that exhibits agonist activity at the μ-opioid receptor. cardioprotective agent Any protective agent that is able to prevent damage to the heart. delta-opioid receptor agonist A compound that exhibits agonist activity at the δ-opioid receptor. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| DADLE (CHEBI:234245) has role antinociceptive agent (CHEBI:228138) |
| DADLE (CHEBI:234245) has role autophagy inducer (CHEBI:138880) |
| DADLE (CHEBI:234245) has role cardioprotective agent (CHEBI:77307) |
| DADLE (CHEBI:234245) has role geroprotector (CHEBI:176497) |
| DADLE (CHEBI:234245) has role neuroprotective agent (CHEBI:63726) |
| DADLE (CHEBI:234245) has role opioid analgesic (CHEBI:35482) |
| DADLE (CHEBI:234245) has role δ-opioid receptor agonist (CHEBI:64054) |
| DADLE (CHEBI:234245) has role μ-opioid receptor agonist (CHEBI:55322) |
| DADLE (CHEBI:234245) is a pentapeptide (CHEBI:48545) |
| IUPAC Name |
|---|
| L-tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine |
| Synonyms | Source |
|---|---|
| BW 180C | DrugBank |
| BW-180C | DrugBank |
| BW180C | DrugBank |
| D-Ala2, D-Leu5-enkephalin | ChEBI |
| [D-Ala2, D-Leu5]-enkephalin | ChEBI |
| enkephalin-(2-D-Ala, 5-D-Leu) | ChEBI |
| Citations |
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