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CHEBI:234200 - rafoxanide

Default Structure
ChEBI IDCHEBI:234200
ChEBI Namerafoxanide
Stars
DefinitionA salicylanilide resulting from the formal condensation of the carboxy group of 2-hydroxy-3,5-diiodobenzoic acid with the amino group of 3-chloro-4-(4-chlorophenoxy)aniline. It is a broad-spectrum anthelmintic used for the treatment of parasitic infections in cattle and sheep.
Last Modified20 June 2025
Submitterdoughowe
DownloadsMolfile
FormulaC19H11Cl2I2NO3
Net Charge0
Average Mass626.015
Monoisotopic Mass624.82054
SMILESO=C(Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1)c1cc(I)cc(I)c1O
InChIInChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChIKeyNEMNPWINWMHUMR-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
DNA synthesis inhibitor  Any substance that inhibits the synthesis of DNA.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
autophagy inducer  Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
chemosensitiser  Any compound that can sensitise tumour cells to chemotherapy.
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
B-Raf inhibitor  A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)
Applications:
anthelminthic drug  Substance intended to kill parasitic worms (helminths).
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
rafoxanide (CHEBI:234200) has role anthelminthic drug (CHEBI:35443)
rafoxanide (CHEBI:234200) has role antibacterial agent (CHEBI:33282)
rafoxanide (CHEBI:234200) has role antifungal agent (CHEBI:35718)
rafoxanide (CHEBI:234200) has role antineoplastic agent (CHEBI:35610)
rafoxanide (CHEBI:234200) has role autophagy inducer (CHEBI:138880)
rafoxanide (CHEBI:234200) has role B-Raf inhibitor (CHEBI:75047)
rafoxanide (CHEBI:234200) has role chemosensitiser (CHEBI:233442)
rafoxanide (CHEBI:234200) has role DNA synthesis inhibitor (CHEBI:59517)
rafoxanide (CHEBI:234200) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
rafoxanide (CHEBI:234200) is a aromatic ether (CHEBI:35618)
rafoxanide (CHEBI:234200) is a benzamides (CHEBI:22702)
rafoxanide (CHEBI:234200) is a monochlorobenzenes (CHEBI:83403)
rafoxanide (CHEBI:234200) is a organoiodine compound (CHEBI:37142)
rafoxanide (CHEBI:234200) is a phenols (CHEBI:33853)
rafoxanide (CHEBI:234200) is a salicylanilides (CHEBI:53468)
rafoxanide (CHEBI:234200) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
INNs  Source
rafoxanidaWHO MedNet
rafoxanideWHO MedNet
rafoxanideWHO MedNet
rafoxanidumWHO MedNet
Synonyms  Source
3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy)salicylanilideChEBI
3,5-diodo-3'-chloro-4'-(p-chlorophenoxy)salicylanilideChEBI
3'-chloro-4'-(4-chlorophenoxy)-3,5-diiodosalicylanilideChEBI
3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilideChEBI
NSC 355278ChEBI
NSC-355278ChEBI
Brand Names  Source
DisalanChEBI
RanideChEBI
Manual XrefsDatabases
D05693KEGG DRUG
OX9PDBeChem
RafoxanideWikipedia
Registry NumbersSources
CAS:22662-39-1ChEBI
Citations