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CHEBI:234200 - rafoxanide

ChEBI IDCHEBI:234200
ChEBI Namerafoxanide
Stars
DefinitionA salicylanilide resulting from the formal condensation of the carboxy group of 2-hydroxy-3,5-diiodobenzoic acid with the amino group of 3-chloro-4-(4-chlorophenoxy)aniline. It is a broad-spectrum anthelmintic used for the treatment of parasitic infections in cattle and sheep.
Last Modified20 June 2025
Submitterdoughowe
DownloadsMolfile
FormulaC19H11Cl2I2NO3
Net Charge0
Average Mass626.015
Monoisotopic Mass624.82054
SMILESO=C(Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1)c1cc(I)cc(I)c1O
InChIInChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChIKeyNEMNPWINWMHUMR-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
autophagy inducer  Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
chemosensitiser  Any compound that can sensitise tumour cells to chemotherapy.
DNA synthesis inhibitor  Any substance that inhibits the synthesis of DNA.
B-Raf inhibitor  A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)
Applications:
anthelminthic drug  Substance intended to kill parasitic worms (helminths).
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
rafoxanide (CHEBI:234200) has role anthelminthic drug (CHEBI:35443)
rafoxanide (CHEBI:234200) has role antibacterial agent (CHEBI:33282)
rafoxanide (CHEBI:234200) has role antifungal agent (CHEBI:35718)
rafoxanide (CHEBI:234200) has role antineoplastic agent (CHEBI:35610)
rafoxanide (CHEBI:234200) has role autophagy inducer (CHEBI:138880)
rafoxanide (CHEBI:234200) has role B-Raf inhibitor (CHEBI:75047)
rafoxanide (CHEBI:234200) has role chemosensitiser (CHEBI:233442)
rafoxanide (CHEBI:234200) has role DNA synthesis inhibitor (CHEBI:59517)
rafoxanide (CHEBI:234200) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
rafoxanide (CHEBI:234200) is a aromatic ether (CHEBI:35618)
rafoxanide (CHEBI:234200) is a benzamides (CHEBI:22702)
rafoxanide (CHEBI:234200) is a monochlorobenzenes (CHEBI:83403)
rafoxanide (CHEBI:234200) is a organoiodine compound (CHEBI:37142)
rafoxanide (CHEBI:234200) is a phenols (CHEBI:33853)
rafoxanide (CHEBI:234200) is a salicylanilides (CHEBI:53468)
rafoxanide (CHEBI:234200) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
INNs  Source
rafoxanidaWHO MedNet
rafoxanidumWHO MedNet
rafoxanideWHO MedNet
rafoxanideWHO MedNet
Synonyms  Source
3'-chloro-4'-(4-chlorophenoxy)-3,5-diiodosalicylanilideChEBI
NSC-355278ChEBI
NSC355278ChEBI
NSC 355278ChEBI
3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilideChEBI
3,5-diodo-3'-chloro-4'-(p-chlorophenoxy)salicylanilideChEBI
Brand Names  Source
RanideChEBI
DisalanChEBI
Manual XrefsDatabases
D05693KEGG DRUG
RafoxanideWikipedia
OX9PDBeChem
Registry NumbersSources
CAS:22662-39-1ChEBI
Citations