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CHEBI:234118 - ampkinone

ChEBI IDCHEBI:234118
ChEBI Nameampkinone
Stars
DefinitionAn organic heterotetracyclic compound that is [1]benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione substituted by 4-benzoylphenyl, methyl, methyl, hydroxy, and methoxy groups at positions 2, 4, 4, 6 and 7, respectively. It is an indirect small-molecule activator of AMPK and a potential therapeutic agent for the treatment of obesity and type 2 diabetes.
Last Modified24 April 2025
SubmitterFlyBase
DownloadsMolfile
FormulaC31H23NO6
Net Charge0
Average Mass505.526
Monoisotopic Mass505.15254
SMILESCOc1ccc2c(c1O)OC(C)(C)c1c-2ccc2c1C(=O)N(c1ccc(C(=O)c3ccccc3)cc1)C2=O
InChIInChI=1S/C31H23NO6/c1-31(2)25-20(21-15-16-23(37-3)27(34)28(21)38-31)13-14-22-24(25)30(36)32(29(22)35)19-11-9-18(10-12-19)26(33)17-7-5-4-6-8-17/h4-16,34H,1-3H3
InChIKeyBRRCHDIWBKOMEC-UHFFFAOYSA-N
Roles Classification
Biological Roles:
protein kinase agonist  An agonist that selectively binds to and activates a protein kinase receptor.
anti-obesity agent  Any substance which is used to reduce or control weight.
Application:
hypoglycemic agent  A drug which lowers the blood glucose level.
ChEBI Ontology
Outgoing Relation(s)
ampkinone (CHEBI:234118) has role anti-obesity agent (CHEBI:74518)
ampkinone (CHEBI:234118) has role hypoglycemic agent (CHEBI:35526)
ampkinone (CHEBI:234118) has role protein kinase agonist (CHEBI:64106)
ampkinone (CHEBI:234118) is a benzophenones (CHEBI:22726)
ampkinone (CHEBI:234118) is a ether (CHEBI:25698)
ampkinone (CHEBI:234118) is a organic heterotetracyclic compound (CHEBI:38163)
IUPAC Name 
2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethylchromeno[3,4-e]isoindole-1,3(2H,4H)-dione
Synonyms  Source
AMPK signaling activator VSUBMITTER
2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethylchromeno[3,4-e]isoindole-1,3-dioneSUBMITTER
2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl[1]benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dioneIUPAC
AMPK activator VChEBI
Registry NumbersSources
CAS:1233082-79-5ChEBI
Citations