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CHEBI:234076 - CT-179

ChEBI IDCHEBI:234076
ChEBI NameCT-179
Stars
DefinitionA member of the class of pyridines that is pyridine substituted by [(3,4-dichlorophenyl)carbamoyl]amino, [3-(dimethylamino)propyl]amino, and methyl groups at positions 2, 4 and 6, respectively. It is a small molecule inhibitor of OLIG2 developed by Curtana Pharmaceuticals for the treatment of glioblastoma, medulloblastoma, and other brain cancers.
Last Modified17 April 2025
Submitterlbonaobra
DownloadsMolfile
FormulaC17H22Cl2N6O
Net Charge0
Average Mass397.310
Monoisotopic Mass396.12321
SMILESCc1cc(NCCCN(C)C)nc(NC(=O)Nc2ccc(Cl)c(Cl)c2)n1
InChIInChI=1S/C17H22Cl2N6O/c1-11-9-15(20-7-4-8-25(2)3)23-16(21-11)24-17(26)22-12-5-6-13(18)14(19)10-12/h5-6,9-10H,4,7-8H2,1-3H3,(H3,20,21,22,23,24,26)
InChIKeyMWEZWAONAIZIAQ-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
OLIG2 inhibitor  Any inhibitor of OLIG2.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
CT-179 (CHEBI:234076) has role antineoplastic agent (CHEBI:35610)
CT-179 (CHEBI:234076) has role OLIG2 inhibitor (CHEBI:234089)
CT-179 (CHEBI:234076) is a dichlorobenzene (CHEBI:23697)
CT-179 (CHEBI:234076) is a phenylureas (CHEBI:134043)
CT-179 (CHEBI:234076) is a pyridines (CHEBI:26421)
CT-179 (CHEBI:234076) is a secondary amino compound (CHEBI:50995)
CT-179 (CHEBI:234076) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
1-(3,4-dichlorophenyl)-3-(4-{[3-(dimethylamino)propyl]amino}-6-methylpyrimidin-2-yl)urea
Synonyms  Source
N-(3,4-dichlorophenyl)-N'-(4-{[3-(dimethylamino)propyl]amino}-6-methylpyrimidin-2-yl)ureaIUPAC
1-(2-(3-(3,4-dichlorophenyl)ureido)-6-methyl-pyrimidin-4-yl)-amino-3(dimethylamino)propaneSUBMITTER
CT179DrugBank
CT 179DrugBank
Manual XrefsDatabases
DB17114DrugBank
WO2016138479Patent
Registry NumbersSources
CAS:1996636-69-1SUBMITTER
Citations