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CHEBI:233640 - dWIZ-2

ChEBI IDCHEBI:233640
ChEBI NamedWIZ-2
Stars
DefinitionA member of the class of isoindoles that is 2,3-dihydro-1H-isoindol-1-one substituted by 2,6-dioxopiperidin-3-yl and [(2R)-1-ethylpiperidin-2-yl]methoxy groups at positions 2 and 5, respectively. It is a molecular glue degrader of the WIZ transcription factor that induces fetal hemoglobin in eythroblasts, and a potential therapeutic agent for the treatment of Sickle cell disease.
Last Modified7 March 2025
Submitterlbonaobra
DownloadsMolfile
FormulaC21H27N3O4
Net Charge0
Average Mass385.464
Monoisotopic Mass385.20016
SMILESCCN1CCCC[C@@H]1COc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O
InChIInChI=1S/C21H27N3O4/c1-2-23-10-4-3-5-15(23)13-28-16-6-7-17-14(11-16)12-24(21(17)27)18-8-9-19(25)22-20(18)26/h6-7,11,15,18H,2-5,8-10,12-13H2,1H3,(H,22,25,26)/t15-,18?/m1/s1
InChIKeyDHFJHVJOMHNTSK-NNJIEVJOSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
ChEBI Ontology
Outgoing Relation(s)
dWIZ-2 (CHEBI:233640) is a aromatic ether (CHEBI:35618)
dWIZ-2 (CHEBI:233640) is a isoindoles (CHEBI:24897)
dWIZ-2 (CHEBI:233640) is a piperidines (CHEBI:26151)
dWIZ-2 (CHEBI:233640) is a piperidones (CHEBI:48589)
dWIZ-2 (CHEBI:233640) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
3-(5-{[(2R)-1-ethylpiperidin-2-yl]methoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
Synonyms  Source
3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dioneSUBMITTER
HbF inducer 2SUBMITTER
dWIZ 2ChEBI
dWIZ2ChEBI
Manual XrefsDatabases
EP4076650Patent
Registry NumbersSources
CAS:2654011-51-3SUBMITTER
Citations