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CHEBI:233475 - Tas-116

ChEBI IDCHEBI:233475
ChEBI NameTas-116
Stars
DefinitionPimitespib is a specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, pimitespib specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.
Submitterlbonaobra
DownloadsMolfile
FormulaC25H26N8O
Net Charge0
Average Mass454.538
Monoisotopic Mass454.22296
SMILESCCc1cc(C(N)=O)ccc1-n1nc(C(C)C)c2c(-n3cnc(-c4cnn(C)c4)c3)ccnc21
InChIInChI=1S/C25H26N8O/c1-5-16-10-17(24(26)34)6-7-20(16)33-25-22(23(30-33)15(2)3)21(8-9-27-25)32-13-19(28-14-32)18-11-29-31(4)12-18/h6-15H,5H2,1-4H3,(H2,26,34)
InChIKeyNVVPMZUGELHVMH-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
Tas-116 (CHEBI:233475) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
PimitespibSUBMITTER
1260533-36-5SUBMITTER
3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamideSUBMITTER
JeselhySUBMITTER
Registry NumbersSources
CAS:1260533-36-5SUBMITTER