suzetrigine (CHEBI:233446)

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CHEBI:233446 - suzetrigine

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ChEBI ID	CHEBI:233446
ChEBI Name	suzetrigine
Stars
Definition	A member of the class of oxolanes that is oxolane substituted by 4-aminoacyl-pyridine-2-carboxamide, 3,4-difluoro-2-methoxyphenyl, methyl, and trifluoromethyl groups at positions 2, 3, 4, 5, and 5, respectively (the 2R,3S,4S,5R-stereoisomer). It is a selective blocker of the Na_V 1.8 voltage-gated sodium channel and has been approved for the treatment of moderate to severe acute pain in adults.
Last Modified	5 February 2025
Submitter	Adnan
Downloads	Molfile

Formula	C21H20F5N3O4
Net Charge	0
Average Mass	473.398
Monoisotopic Mass	473.13740
SMILES	COc1c([C@H]2[C@H](C(=O)Nc3ccnc(C(N)=O)c3)O[C@@](C)(C(F)(F)F)[C@H]2C)ccc(F)c1F
InChI	InChI=1S/C21H20F5N3O4/c1-9-14(11-4-5-12(22)15(23)16(11)32-3)17(33-20(9,2)21(24,25)26)19(31)29-10-6-7-28-13(8-10)18(27)30/h4-9,14,17H,1-3H3,(H2,27,30)(H,28,29,31)/t9-,14-,17+,20+/m0/s1
InChIKey	XSQUJFKRXZMOKA-PAFIKIDNSA-N

Wikipedia

Roles Classification

Biological Roles:	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. voltage-gated sodium channel blocker Any sodium channel blocker that interferes with the activity of voltage-gated sodium channels.
Application:	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.

ChEBI Ontology

Outgoing Relation(s)
	suzetrigine (CHEBI:233446) has role non-narcotic analgesic (CHEBI:35481)
	suzetrigine (CHEBI:233446) has role voltage-gated sodium channel blocker (CHEBI:38634)
	suzetrigine (CHEBI:233446) is a difluorobenzene (CHEBI:38582)
	suzetrigine (CHEBI:233446) is a monomethoxybenzene (CHEBI:25235)
	suzetrigine (CHEBI:233446) is a oxolanes (CHEBI:26912)
	suzetrigine (CHEBI:233446) is a primary carboxamide (CHEBI:140324)
	suzetrigine (CHEBI:233446) is a pyridinecarboxamide (CHEBI:25529)
	suzetrigine (CHEBI:233446) is a secondary carboxamide (CHEBI:140325)

IUPAC Name
4-({[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-yl]carbonyl}amino)pyridine-2-carboxamide

INNs	Source
suzétrigine	WHO MedNet
suzetrigine	WHO MedNet
suzetrigina	WHO MedNet
suzetriginum	WHO MedNet

Synonyms	Source
VX-548	DrugBank
VX548	DrugBank
VX 548	DrugBank
4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine-2-carboxamide	ChEBI

Brand Name	Source
JOURNAVX	ChEBI

Manual Xrefs	Databases
DB18927	DrugBank
D12860	KEGG DRUG
Suzetrigine	Wikipedia
WO2021113627	Patent

Registry Numbers	Sources
CAS:2649467-58-1	KEGG DRUG

Citations