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CHEBI:233363 - A-485

Default Structure
ChEBI IDCHEBI:233363
ChEBI NameA-485
Stars
DefinitionA-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively.
Submitterlbonaobra
DownloadsMolfile
FormulaC25H24F4N4O5
Net Charge0
Average Mass536.482
Monoisotopic Mass536.16828
SMILESCNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O
InChIInChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1
InChIKeyVRVJKILQRBSEAG-LFPIHBKWSA-N
ChEBI Ontology
Outgoing Relation(s)
A-485 (CHEBI:233363) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
1889279-16-6SUBMITTER
N-(4-fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamideSUBMITTER
Registry NumbersSources
CAS:1889279-16-6SUBMITTER