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CHEBI:233303 - Quinacrine dihydrochloride dihydrate

Default Structure
ChEBI IDCHEBI:233303
ChEBI NameQuinacrine dihydrochloride dihydrate
Stars
DefinitionQuinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.
Submitterlbonaobra
DownloadsMolfile
FormulaC23H30ClN3O.2H2O.2HCl
Net Charge0
Average Mass508.918
Monoisotopic Mass507.18223
SMILESCCN(CC)CCCC(C)/N=c1\c2ccc(Cl)cc2nc2ccc(OC)cc12.Cl.Cl.O.O
InChIInChI=1S/C23H30ClN3O.2ClH.2H2O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H;2*1H2
InChIKeyRZFNKJVCPDLQQA-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
Quinacrine dihydrochloride dihydrate (CHEBI:233303) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrate;dihydrochlorideSUBMITTER
6151-30-0SUBMITTER
Atabrine hydrochlorideSUBMITTER
Mepacrine hydrochlorideSUBMITTER
Quinacrine hydrochlorideSUBMITTER
Registry NumbersSources
CAS:6151-30-0SUBMITTER