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CHEBI:233197 - devimistat

ChEBI IDCHEBI:233197
ChEBI Namedevimistat
Stars
DefinitionA racemate comprising equimolar amounts of (6R)-6,8-bis(benzylsulfanyl)octanoic acid and its enantiomer, (6S)-6,8-bis(benzylsulfanyl)octanoic acid. It is an inhibitor of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase enzymes, and currently in development for the treatment of pancreatic cancer and acute myeloid leukemia.
Last Modified3 April 2025
SubmitterFlyBase
FormulaC22H28O2S2
Net Charge0
Average Mass388.598
Monoisotopic Mass388.15307
Wikipedia
Roles Classification
Biological Role:
EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of pyruvate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.2).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
devimistat (CHEBI:233197) has part (6R)-6,8-bis(benzylsulfanyl)octanoic acid (CHEBI:233959)
devimistat (CHEBI:233197) has part (6S)-6,8-bis(benzylsulfanyl)octanoic acid (CHEBI:233960)
devimistat (CHEBI:233197) has role antineoplastic agent (CHEBI:35610)
devimistat (CHEBI:233197) has role EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor (CHEBI:176961)
devimistat (CHEBI:233197) is a racemate (CHEBI:60911)
INNs  Source
dévimistatWHO MedNet
devimistatumWHO MedNet
devimistatWHO MedNet
devimistatWHO MedNet
Synonyms  Source
CPI-613SUBMITTER
CPI 613ChEBI
CPI613ChEBI
Manual XrefsDatabases
DB12109DrugBank
DevimistatWikipedia
Registry NumbersSources
CAS:95809-78-2ChEBI
Citations