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CHEBI:233052 - RG-2833

ChEBI IDCHEBI:233052
ChEBI NameRG-2833
Stars
DefinitionA secondary carboxamide resulting from the formal condensation of the carboxy group of 4-methylbenzoic acid with the primary amino group of 6-amino-N-(2-aminophenyl)hexanamide. It is a HDAC1 and HDAC3 inhibitor with established brain penetration.
Last Modified2 April 2025
SubmitterFlyBase
DownloadsMolfile
FormulaC20H25N3O2
Net Charge0
Average Mass339.439
Monoisotopic Mass339.19468
SMILESCc1ccc(C(=O)NCCCCCC(=O)Nc2ccccc2N)cc1
InChIInChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
InChIKeyVOPDXHFYDJAYNS-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 3.5.1.98 (histone deacetylase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Applications:
nootropic agent  Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
RG-2833 (CHEBI:233052) has functional parent 6-aminohexanoic acid (CHEBI:16586)
RG-2833 (CHEBI:233052) has role antineoplastic agent (CHEBI:35610)
RG-2833 (CHEBI:233052) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
RG-2833 (CHEBI:233052) has role nootropic agent (CHEBI:66980)
RG-2833 (CHEBI:233052) is a anilide (CHEBI:13248)
RG-2833 (CHEBI:233052) is a benzamides (CHEBI:22702)
RG-2833 (CHEBI:233052) is a secondary carboxamide (CHEBI:140325)
RG-2833 (CHEBI:233052) is a substituted aniline (CHEBI:48975)
RG-2833 (CHEBI:233052) is a toluenes (CHEBI:27024)
IUPAC Name 
N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide
Synonyms  Source
RGFP 109DrugBank
RG 2833DrugBank
RGFP-109DrugBank
RGFP109DrugBank
RG2833DrugBank
HDACi-109ChEBI
Manual XrefsDatabases
DB16955DrugBank
Registry NumbersSources
CAS:1215493-56-3SUBMITTER
Citations