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CHEBI:233052 - RG-2833

Default Structure
ChEBI IDCHEBI:233052
ChEBI NameRG-2833
Stars
DefinitionA secondary carboxamide resulting from the formal condensation of the carboxy group of 4-methylbenzoic acid with the primary amino group of 6-amino-N-(2-aminophenyl)hexanamide. It is a HDAC1 and HDAC3 inhibitor with established brain penetration.
Last Modified2 April 2025
SubmitterFlyBase
DownloadsMolfile
FormulaC20H25N3O2
Net Charge0
Average Mass339.439
Monoisotopic Mass339.19468
SMILESCc1ccc(C(=O)NCCCCCC(=O)Nc2ccccc2N)cc1
InChIInChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
InChIKeyVOPDXHFYDJAYNS-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 3.5.1.98 (histone deacetylase) inhibitor  An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
nootropic agent  Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
ChEBI Ontology
Outgoing Relation(s)
RG-2833 (CHEBI:233052) has functional parent 6-aminohexanoic acid (CHEBI:16586)
RG-2833 (CHEBI:233052) has role antineoplastic agent (CHEBI:35610)
RG-2833 (CHEBI:233052) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
RG-2833 (CHEBI:233052) has role nootropic agent (CHEBI:66980)
RG-2833 (CHEBI:233052) is a anilide (CHEBI:13248)
RG-2833 (CHEBI:233052) is a benzamides (CHEBI:22702)
RG-2833 (CHEBI:233052) is a secondary carboxamide (CHEBI:140325)
RG-2833 (CHEBI:233052) is a substituted aniline (CHEBI:48975)
RG-2833 (CHEBI:233052) is a toluenes (CHEBI:27024)
IUPAC Name 
N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide
Synonyms  Source
N-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamideDrugBank
HDACi 109ChEBI
HDACi-109ChEBI
RG 2833DrugBank
RG2833DrugBank
RGFP 109DrugBank
Manual XrefsDatabases
DB16955DrugBank
Registry NumbersSources
CAS:1215493-56-3SUBMITTER
Citations