EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:232587 - LLY283

Default Structure
ChEBI IDCHEBI:232587
ChEBI NameLLY283
Stars
DefinitionLLY-283 is a novel and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). LLY-283 inhibits PRMT5 enzymatic activity in vitro and in cells with IC50 of 22 nM and 25 nM, respectively. LLY-283 shows antitumor activity.
Submitterruixy
DownloadsMolfile
FormulaC17H18N4O4
Net Charge0
Average Mass342.355
Monoisotopic Mass342.13281
SMILES[H][C@]1(O)[C@@]([H])(O)[C@]([H])(n2ccc3c(N)ncnc32)O[C@]1([H])[C@]([H])(O)c1ccccc1
InChIInChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8,11-14,17,22-24H,(H2,18,19,20)/t11-,12+,13-,14-,17-/m1/s1
InChIKeyWWOOWAHTEXIWBO-QFRSUPTLSA-N
ChEBI Ontology
Outgoing Relation(s)
LLY283 (CHEBI:232587) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diolSUBMITTER
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineSUBMITTER
LLY-283SUBMITTER
Registry NumbersSources
CAS:2040291-27-6SUBMITTER