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CHEBI:232328 - dordaviprone

Default Structure
ChEBI IDCHEBI:232328
ChEBI Namedordaviprone
Stars
DefinitionAn organic heterotricyclic compound that is 2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one substituted by 2-methylbenzyl and benzyl groups at positions 4 and 7, respectively. It is a selective antagonist of the dopamine receptor D2 and an allosteric agonist of mitochondrial protease caseinolytic protease P.
Last Modified29 October 2024
SubmitterBrianna Xu
DownloadsMolfile
FormulaC24H26N4O
Net Charge0
Average Mass386.499
Monoisotopic Mass386.21066
SMILESCc1ccccc1CN1C(=O)C2=C(CCN(Cc3ccccc3)C2)N2CCN=C12
InChIInChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
InChIKeyVLULRUCCHYVXOH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
dopamine receptor D2 antagonist  An antagonist that binds to and deactivates the dopamine receptor D2, the main receptor for all antipsychotic drugs.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
dordaviprone (CHEBI:232328) has role antineoplastic agent (CHEBI:35610)
dordaviprone (CHEBI:232328) has role apoptosis inducer (CHEBI:68495)
dordaviprone (CHEBI:232328) has role dopamine receptor D2 antagonist (CHEBI:131787)
dordaviprone (CHEBI:232328) is a benzenes (CHEBI:22712)
dordaviprone (CHEBI:232328) is a organic heterotricyclic compound (CHEBI:26979)
dordaviprone (CHEBI:232328) is a toluenes (CHEBI:27024)
IUPAC Name 
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
INNs  Source
dordavipronaWHO MedNet
dordaviproneWHO MedNet
dordaviproneWHO MedNet
dordavipronumWHO MedNet
Synonyms  Source
11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-oneSUBMITTER
ONC 201SUBMITTER
ONC-201DrugBank
ONC201DrugBank
TIC 10ChEBI
TIC-10DrugBank
Manual XrefsDatabases
D12733KEGG DRUG
DB14844DrugBank
DordaviproneWikipedia
Registry NumbersSources
CAS:1616632-77-9DrugBank
Citations