EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:232328 - dordaviprone

ChEBI IDCHEBI:232328
ChEBI Namedordaviprone
Stars
DefinitionAn organic heterotricyclic compound that is 2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one substituted by 2-methylbenzyl and benzyl groups at positions 4 and 7, respectively. It is a selective antagonist of the dopamine receptor D2 and an allosteric agonist of mitochondrial protease caseinolytic protease P.
Last Modified29 October 2024
SubmitterBrianna Xu
DownloadsMolfile
FormulaC24H26N4O
Net Charge0
Average Mass386.499
Monoisotopic Mass386.21066
SMILESCc1ccccc1CN1C(=O)C2=C(CCN(Cc3ccccc3)C2)N2CCN=C12
InChIInChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
InChIKeyVLULRUCCHYVXOH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
dopamine receptor D2 antagonist  An antagonist that binds to and deactivates the dopamine receptor D2, the main receptor for all antipsychotic drugs.
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
dordaviprone (CHEBI:232328) has role antineoplastic agent (CHEBI:35610)
dordaviprone (CHEBI:232328) has role apoptosis inducer (CHEBI:68495)
dordaviprone (CHEBI:232328) has role dopamine receptor D2 antagonist (CHEBI:131787)
dordaviprone (CHEBI:232328) is a benzenes (CHEBI:22712)
dordaviprone (CHEBI:232328) is a organic heterotricyclic compound (CHEBI:26979)
dordaviprone (CHEBI:232328) is a toluenes (CHEBI:27024)
IUPAC Name 
7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
INNs  Source
dordavipronaWHO MedNet
dordavipronumWHO MedNet
dordaviproneWHO MedNet
dordaviproneWHO MedNet
Synonyms  Source
11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-oneSUBMITTER
ONC-201DrugBank
ONC 201SUBMITTER
ONC201DrugBank
TIC-10DrugBank
TIC10DrugBank
Manual XrefsDatabases
DordaviproneWikipedia
DB14844DrugBank
D12733KEGG DRUG
Registry NumbersSources
CAS:1616632-77-9DrugBank
Citations