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CHEBI:231945 - ZG-2291

ChEBI IDCHEBI:231945
ChEBI NameZG-2291
Stars
DefinitionA member of the class of isoxazoles that is 1,2-oxazole substituted by 3-chlorophenyl and 6-[(carboxymethyl)carbamoyl]-5-hydroxypyridin-3-yl groups at positions 3 and 5, respectively. It is a potent inhibitor of factor inhibiting HIF (FIH) and a potential treatment for obesity.
Last Modified11 September 2024
SubmitterAdnan
DownloadsMolfile
FormulaC17H12ClN3O5
Net Charge0
Average Mass373.752
Monoisotopic Mass373.04655
SMILESO=C(O)CNC(=O)c1ncc(-c2cc(-c3cccc(Cl)c3)no2)cc1O
InChIInChI=1S/C17H12ClN3O5/c18-11-3-1-2-9(4-11)12-6-14(26-21-12)10-5-13(22)16(19-7-10)17(25)20-8-15(23)24/h1-7,22H,8H2,(H,20,25)(H,23,24)
InChIKeyLXJZOEXMNSUCFH-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
anti-obesity agent  Any substance which is used to reduce or control weight.
ChEBI Ontology
Outgoing Relation(s)
ZG-2291 (CHEBI:231945) has role anti-obesity agent (CHEBI:74518)
ZG-2291 (CHEBI:231945) is a isoxazoles (CHEBI:55373)
ZG-2291 (CHEBI:231945) is a monocarboxylic acid (CHEBI:25384)
ZG-2291 (CHEBI:231945) is a monochlorobenzenes (CHEBI:83403)
ZG-2291 (CHEBI:231945) is a monohydroxypyridine (CHEBI:38182)
ZG-2291 (CHEBI:231945) is a pyridinecarboxamide (CHEBI:25529)
ZG-2291 (CHEBI:231945) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
N-({5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-hydroxypyridin-2-yl}carbonyl)glycine
Synonyms  Source
ZG 2291ChEBI
ZG2291ChEBI
2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acidPDBeChem
[({5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-hydroxypyridin-2-yl}carbonyl)amino]acetic acidIUPAC
Manual XrefsDatabases
P5IPDBeChem
Citations