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CHEBI:231698 - Obatoclax

Default Structure
ChEBI IDCHEBI:231698
ChEBI NameObatoclax
Stars
DefinitionObatoclax is a small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously. (NCIt)
Submitteramillett1
DownloadsMolfile
FormulaC20H19N3O
Net Charge0
Average Mass317.392
Monoisotopic Mass317.15281
SMILESCOc1c/c(=C2\C=c3ccccc3=N2)n/c1=C\c1nc(C)cc1C
InChIInChI=1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21,23H,1-3H3/b18-17-,19-10-
InChIKeyCVCLJVVBHYOXDC-IAZSKANUSA-N
ChEBI Ontology
Outgoing Relation(s)
Obatoclax (CHEBI:231698) is a organic molecular entity (CHEBI:50860)
Synonym  Source
2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indoleSUBMITTER
Registry NumbersSources
CAS:803712-67-6SUBMITTER