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CHEBI:231694 - serdemetan

Default Structure
ChEBI IDCHEBI:231694
ChEBI Nameserdemetan
Stars
DefinitionSerdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.
Submitterruixy
DownloadsMolfile
FormulaC21H20N4
Net Charge0
Average Mass328.419
Monoisotopic Mass328.16880
SMILESc1ccc2c(CCNc3ccc(N=c4ccncc4)cc3)cnc2c1
InChIInChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKeyCEGSUKYESLWKJP-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
serdemetan (CHEBI:231694) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamineSUBMITTER
JNJ 26854165SUBMITTER
JNJ-26854165SUBMITTER
Registry NumbersSources
CAS:881202-45-5SUBMITTER