capmatinib (CHEBI:231693)

CHEBI:231693 - capmatinib

ChEBI ID	CHEBI:231693
ChEBI Name	capmatinib
Stars
Definition	A member of the class of imidazotriazines that is imidazo[1,2-b][1,2,4]triazine substituted by 3-fluoro-4-(methylcarbamoyl)phenyl and quinolin-6-ylmethyl groups at positions 2 and 7, respectively. It is a c-Met receptor tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer with MET exon 14 skipping mutation.
Last Modified	9 September 2024
Submitter	amillett1
Downloads	Molfile

Formula	C23H17FN6O
Net Charge	0
Average Mass	412.428
Monoisotopic Mass	412.14479
SMILES	CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F
InChI	InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey	LIOLIMKSCNQPLV-UHFFFAOYSA-N

Wikipedia

Roles Classification

hepatotoxic agent A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals.

apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

c-Met tyrosine kinase inhibitor An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology

Outgoing Relation(s)
	capmatinib (CHEBI:231693) has role antineoplastic agent (CHEBI:35610)
	capmatinib (CHEBI:231693) has role apoptosis inducer (CHEBI:68495)
	capmatinib (CHEBI:231693) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
	capmatinib (CHEBI:231693) has role hepatotoxic agent (CHEBI:50908)
	capmatinib (CHEBI:231693) is a benzamides (CHEBI:22702)
	capmatinib (CHEBI:231693) is a imidazotriazine (CHEBI:46906)
	capmatinib (CHEBI:231693) is a monofluorobenzenes (CHEBI:83575)
	capmatinib (CHEBI:231693) is a quinolines (CHEBI:26513)
	capmatinib (CHEBI:231693) is a secondary carboxamide (CHEBI:140325)

IUPAC Name
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Registry Numbers	Sources
CAS:1197376-85-4	SUBMITTER

Citations