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CHEBI:231690 - SCH529074

Default Structure
ChEBI IDCHEBI:231690
ChEBI NameSCH529074
Stars
DefinitionSCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 uM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC). (MedChemExpress)
Submitteramillett1
DownloadsMolfile
FormulaC31H36Cl2N6
Net Charge0
Average Mass563.577
Monoisotopic Mass562.23785
SMILESCN(C)CCCNc1nc(CN2CCN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)nc2ccccc12
InChIInChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36)
InChIKeyNCAJLQDPTZBGJV-UHFFFAOYSA-N
ChEBI Ontology
Outgoing Relation(s)
SCH529074 (CHEBI:231690) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
N'-(2-{4-[bis-(4-chlorophenyl)methyl]piperazin-1-ylmethyl}quinazolin-4-yl)-N,N-dimethylpropane-1,3-diamineSUBMITTER
SCH 529074SUBMITTER
SCH-529074SUBMITTER