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CHEBI:231662 - SH-1280

ChEBI IDCHEBI:231662
ChEBI NameSH-1280
Stars
DefinitionA chromene that is 2,2-dimethyl-2H-chromene substituted by methoxy and (2S)-2-(3,4-dimethoxyphenyl)propanoyl groups at positions 5 and 6, respectively. It is a Hsp90 inhibitor that prevents hypoxia-mediated retinal neovascularization and could potentially be used as a treatment for diabetic retinopathy.
Last Modified10 September 2024
Submitteramillett1
DownloadsMolfile
FormulaC23H26O5
Net Charge0
Average Mass382.456
Monoisotopic Mass382.17802
SMILESCOc1ccc([C@H](C)C(=O)c2ccc3c(c2OC)C=CC(C)(C)O3)cc1OC
InChIInChI=1S/C23H26O5/c1-14(15-7-9-19(25-4)20(13-15)26-5)21(24)17-8-10-18-16(22(17)27-6)11-12-23(2,3)28-18/h7-14H,1-6H3/t14-/m0/s1
InChIKeyGUQCQOSQMZKFIE-AWEZNQCLSA-N
Roles Classification
Biological Role:
Hsp90 inhibitor  An EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
ChEBI Ontology
Outgoing Relation(s)
SH-1280 (CHEBI:231662) has role Hsp90 inhibitor (CHEBI:63962)
SH-1280 (CHEBI:231662) is a aromatic ether (CHEBI:35618)
SH-1280 (CHEBI:231662) is a aromatic ketone (CHEBI:76224)
SH-1280 (CHEBI:231662) is a chromenes (CHEBI:23232)
SH-1280 (CHEBI:231662) is a dimethoxybenzene (CHEBI:51681)
IUPAC Name 
(2S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one
Synonyms  Source
(2S)-2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)propan-1-oneIUPAC
SH1280ChEBI
SH 1280ChEBI
Citations