CHEBI:231621 - tasisulam

ChEBI IDCHEBI:231621
ChEBI Nametasisulam
Stars
DefinitionA thiophene substituted by a 2,4-dichlorobenzamide-N-sulfonyl and bromo groups at positions 2 and 4, respectively. It induces tumour cell apoptosis via ROS induction and mitochondrial membrane potential loss and currently in clinical development for the treatment of cancer.
Last Modified28 June 2024
Submitteramillett1
DownloadsMolfile
FormulaC11H6BrCl2NO3S2
Net Charge0
Average Mass415.117
Monoisotopic Mass412.83495
SMILESO=C(NS(=O)(=O)c1ccc(Br)s1)c1ccc(Cl)cc1Cl
InChIInChI=1S/C11H6BrCl2NO3S2/c12-9-3-4-10(19-9)20(17,18)15-11(16)7-2-1-6(13)5-8(7)14/h1-5H,(H,15,16)
InChIKeyWWONFUQGBVOKOF-UHFFFAOYSA-N
Roles Classification
Biological Role:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Applications:
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
tasisulam (CHEBI:231621) has role angiogenesis inhibitor (CHEBI:48422)
tasisulam (CHEBI:231621) has role antineoplastic agent (CHEBI:35610)
tasisulam (CHEBI:231621) has role apoptosis inducer (CHEBI:68495)
tasisulam (CHEBI:231621) is a N-sulfonylcarboxamide (CHEBI:90852)
tasisulam (CHEBI:231621) is a dichlorobenzene (CHEBI:23697)
tasisulam (CHEBI:231621) is a organobromine compound (CHEBI:37141)
tasisulam (CHEBI:231621) is a thiophenes (CHEBI:26961)
IUPAC Name 
N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichlorobenzamide
INNs  Source
tasisulamWHO MedNet
tasisulamWHO MedNet
tasisulamWHO MedNet
tasisulamumWHO MedNet
Synonyms  Source
N-(2,4-dichlorobenzoyl)-5-bromothiophene-2-sulfonamideSUBMITTER
N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamideSUBMITTER
LY 573636ChEBI
LY573636ChEBI
LY-573636ChEBI
Manual XrefsDatabases
DB11941DrugBank
P7MPDBeChem
Registry NumbersSources
CAS:519055-62-0DrugBank
Citations