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CHEBI:231605 - telaglenastat

ChEBI IDCHEBI:231605
ChEBI Nametelaglenastat
Stars
DefinitionTelaglenastat is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.
Last Modified2 August 2024
Submitterruixy
DownloadsMolfile
FormulaC26H24F3N7O3S
Net Charge0
Average Mass571.585
Monoisotopic Mass571.16134
SMILESO=C(Cc1cccc(OC(F)(F)F)c1)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1
InChIInChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
InChIKeyPRAAPINBUWJLGA-UHFFFAOYSA-N
Roles Classification
Biological Role:
EC 3.5.1.2 (glutaminase) inhibitor  Any EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of a glutaminase (EC 3.5.1.2) and thus the generation of glutamate from glutamine.
ChEBI Ontology
Outgoing Relation(s)
telaglenastat (CHEBI:231605) has role EC 3.5.1.2 (glutaminase) inhibitor (CHEBI:60280)
telaglenastat (CHEBI:231605) is a pyridines (CHEBI:26421)
INNs  Source
telaglenastatWHO MedNet
telaglenastatumWHO MedNet
telaglenastatWHO MedNet
télaglénastatWHO MedNet
Synonyms  Source
CB-839DrugBank
N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamideSUBMITTER
2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamideSUBMITTER
Manual XrefsDatabases
DB15232DrugBank
HMDB0249712HMDB
D11738KEGG DRUG
63JPDBeChem
Registry NumbersSources
CAS:1439399-58-2KEGG DRUG
Citations