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CHEBI:231369 - savolitinib

ChEBI IDCHEBI:231369
ChEBI Namesavolitinib
Stars
DefinitionA member of the class of triazolopyrazines that is 1H-[1,2,3]triazolo[4,5-b]pyrazine substituted by (1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl and 1-methyl-1H-pyrazol-4-yl groups at positions 1 and 6, respectively. It is a highly selective MET tyrosine kinase inhibitor that is approved in China for advanced NSCLC with MET exon 14 skipping mutations.
Last Modified9 May 2024
Submitterdelphine
DownloadsMolfile
FormulaC17H15N9
Net Charge0
Average Mass345.370
Monoisotopic Mass345.14504
SMILESC[C@@H](c1ccc2nccn2c1)n1nnc2ncc(-c3cnn(C)c3)nc21
InChIInChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChIKeyXYDNMOZJKOGZLS-NSHDSACASA-N
Wikipedia
Roles Classification
Biological Role:
c-Met tyrosine kinase inhibitor  An EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor that interferes with the action of c-Met tyrosine kinase.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
savolitinib (CHEBI:231369) has role antineoplastic agent (CHEBI:35610)
savolitinib (CHEBI:231369) has role c-Met tyrosine kinase inhibitor (CHEBI:90199)
savolitinib (CHEBI:231369) is a imidazopyridine (CHEBI:46908)
savolitinib (CHEBI:231369) is a pyrazoles (CHEBI:26410)
savolitinib (CHEBI:231369) is a triazolopyrazine (CHEBI:48277)
IUPAC Name 
1-[(1S)-1-(imidazo[1,2-a]pyridin-6-yl)ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine
INNs  Source
savolitinibWHO MedNet
savolitinibWHO MedNet
savolitinibumWHO MedNet
savolitinibWHO MedNet
Synonyms  Source
volitinibDrugBank
AZD6094DrugBank
AZD-6094SUBMITTER
AZD 6094ChEBI
HMPL-504DrugBank
1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazineChEBI
Brand Name  Source
OrpathysChEBI
Manual XrefsDatabases
DB12048DrugBank
D11139KEGG DRUG
SavolitinibWikipedia
V0LPDBeChem
Registry NumbersSources
CAS:1313725-88-0KEGG DRUG
Citations