telatinib (CHEBI:231351)

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CHEBI:231351 - telatinib

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ChEBI ID	CHEBI:231351
ChEBI Name	telatinib
Stars
Definition	A member of the class of furopyridazines that is furo[2,3-d]pyridazine substituted by (4-chlorophenyl)amino and [2-(methylcarbamoyl)pyridin-4-yl]methoxy groups at positions 4 and 7, respectively. It is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα.
Last Modified	10 May 2024
Submitter	delphine
Downloads	Molfile

Formula	C20H16ClN5O3
Net Charge	0
Average Mass	409.833
Monoisotopic Mass	409.09417
SMILES	CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
InChI	InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
InChIKey	QFCXANHHBCGMAS-UHFFFAOYSA-N

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor.
Applications:	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology

Outgoing Relation(s)
	telatinib (CHEBI:231351) has role angiogenesis inhibitor (CHEBI:48422)
	telatinib (CHEBI:231351) has role antineoplastic agent (CHEBI:35610)
	telatinib (CHEBI:231351) has role apoptosis inducer (CHEBI:68495)
	telatinib (CHEBI:231351) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
	telatinib (CHEBI:231351) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
	telatinib (CHEBI:231351) is a anilines (CHEBI:22562)
	telatinib (CHEBI:231351) is a aromatic ether (CHEBI:35618)
	telatinib (CHEBI:231351) is a furopyridazine (CHEBI:231410)
	telatinib (CHEBI:231351) is a monochlorobenzenes (CHEBI:83403)
	telatinib (CHEBI:231351) is a pyridinecarboxamide (CHEBI:25529)

IUPAC Name
4-({[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxy}methyl)-N-methylpyridine-2-carboxamide

INNs	Source
telatinib	WHO MedNet
telatinibum	WHO MedNet
télatinib	WHO MedNet
telatinib	WHO MedNet

Synonyms	Source
BAY 57-9352	SUBMITTER
4-(((4-((4-chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide	ChEBI
4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide	ChEBI
BAY-579352	ChEBI
BAY-57-9352	ChEBI

Manual Xrefs	Databases
DB15393	DrugBank
HMDB0258783	HMDB

Registry Numbers	Sources
CAS:332012-40-5	SUBMITTER

Citations