telatinib (CHEBI:231351)

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CHEBI:231351 - telatinib

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ChEBI ID	CHEBI:231351
ChEBI Name	telatinib
Stars
Definition	A member of the class of furopyridazines that is furo[2,3-d]pyridazine substituted by (4-chlorophenyl)amino and [2-(methylcarbamoyl)pyridin-4-yl]methoxy groups at positions 4 and 7, respectively. It is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα.
Last Modified	10 May 2024
Submitter	delphine
Downloads	Molfile

Formula	C20H16ClN5O3
Net Charge	0
Average Mass	409.833
Monoisotopic Mass	409.09417
SMILES	CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
InChI	InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
InChIKey	QFCXANHHBCGMAS-UHFFFAOYSA-N

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Applications:	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology

Outgoing Relation(s)
	telatinib (CHEBI:231351) has role angiogenesis inhibitor (CHEBI:48422)
	telatinib (CHEBI:231351) has role antineoplastic agent (CHEBI:35610)
	telatinib (CHEBI:231351) has role apoptosis inducer (CHEBI:68495)
	telatinib (CHEBI:231351) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
	telatinib (CHEBI:231351) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
	telatinib (CHEBI:231351) is a anilines (CHEBI:22562)
	telatinib (CHEBI:231351) is a aromatic ether (CHEBI:35618)
	telatinib (CHEBI:231351) is a furopyridazine (CHEBI:231410)
	telatinib (CHEBI:231351) is a monochlorobenzenes (CHEBI:83403)
	telatinib (CHEBI:231351) is a pyridinecarboxamide (CHEBI:25529)

IUPAC Name
4-({[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxy}methyl)-N-methylpyridine-2-carboxamide

INNs	Source
telatinib	WHO MedNet
telatinib	WHO MedNet
télatinib	WHO MedNet
telatinibum	WHO MedNet

Synonyms	Source
4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide	ChEBI
4-(((4-((4-chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide	ChEBI
BAY 57-9352	SUBMITTER
BAY-57-9352	ChEBI
BAY-579352	ChEBI

Manual Xrefs	Databases
DB15393	DrugBank
HMDB0258783	HMDB

Registry Numbers	Sources
CAS:332012-40-5	SUBMITTER

Citations