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CHEBI:231344 - talazoparib

Default Structure
ChEBI IDCHEBI:231344
ChEBI Nametalazoparib
Stars
DefinitionTalazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
Submitterdelphine
DownloadsMolfile
FormulaC19H14F2N6O
Net Charge0
Average Mass380.358
Monoisotopic Mass380.11972
SMILESCn1ncnc1[C@H]1c2nnc(=O)c3cc(F)cc(c23)N[C@@H]1c1ccc(F)cc1
InChIInChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChIKeyHWGQMRYQVZSGDQ-HZPDHXFCSA-N
Roles Classification
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
talazoparib (CHEBI:231344) has role antineoplastic agent (CHEBI:35610)
talazoparib (CHEBI:231344) is a organic molecular entity (CHEBI:50860)
Synonyms  Source
BMN 673SUBMITTER
BMN-673SUBMITTER
BMN673SUBMITTER
LT-673ChEMBL
PF-06944076ChEMBL
TalazoparibChEMBL
Registry NumbersSources
CAS:1207456-01-6SUBMITTER
Citations