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CHEBI:229924 - pifithrin-α hydrobromide

ChEBI IDCHEBI:229924
ChEBI Namepifithrin-α hydrobromide
Stars
ASCII Namepifithrin-alpha hydrobromide
DefinitionA hydrobromide salt prepared from 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone and one equivalent of hydrogen bromide. It is a chemical that inhibits p53-mediated gene activation and apoptosis.
Last Modified14 March 2025
SubmitterMetaboLights
DownloadsMolfile
FormulaC16H18N2OS.HBr
Net Charge0
Average Mass367.312
Monoisotopic Mass366.04015
SMILESBr.Cc1ccc(C(=O)Cn2c3c(sc2=N)CCCC3)cc1
InChIInChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
InChIKeyHAGVCKULCLQGRF-UHFFFAOYSA-N
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) feces (BTO:0000440) MetaboLights (MTBLS9087)
Roles Classification
Biological Roles:
p53 inhibitor  Any inhibitor of tumour protein p53.
aryl hydrocarbon receptor agonist  An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).
apoptosis inhibitor  Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
hepatoprotective agent  Any compound that is able to prevent damage to the liver.
ChEBI Ontology
Outgoing Relation(s)
pifithrin-α hydrobromide (CHEBI:229924) has part 3-[2-(4-methylphenyl)-2-oxoethyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-2(3H)-iminium (CHEBI:233675)
pifithrin-α hydrobromide (CHEBI:229924) has role apoptosis inhibitor (CHEBI:68494)
pifithrin-α hydrobromide (CHEBI:229924) has role aryl hydrocarbon receptor agonist (CHEBI:72768)
pifithrin-α hydrobromide (CHEBI:229924) has role hepatoprotective agent (CHEBI:62868)
pifithrin-α hydrobromide (CHEBI:229924) has role p53 inhibitor (CHEBI:232442)
pifithrin-α hydrobromide (CHEBI:229924) is a hydrobromide (CHEBI:48367)
IUPAC Name 
2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone hydrobromide
Synonyms  Source
pifithrin-αChEBI
PFT-αChEBI
2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromideChEBI
PFTαChEBI
Manual XrefsDatabases
19952120ChemSpider
Registry NumbersSources
CAS:63208-82-2ChEBI
Citations