zilucoplan sodium (CHEBI:229660)

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:229660 - zilucoplan sodium

ChEBI ID	CHEBI:229660
ChEBI Name	zilucoplan sodium
Stars
Definition	An organic sodium salt that is the tetrasodium salt of zilucoplan. It is a complement component 5 inhibitor approved for the treatment of generalized myasthenia gravis in adult patients who are anti-acetylcholine receptor antibody positive.
Last Modified	16 April 2024
Submitter	Adnan
Downloads	Molfile

Formula	C172H274N24O55.5Na
Net Charge	+1
Average Mass	3673.147
Monoisotopic Mass	3670.88644
SMILES	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)[O-])NC(=O)[C@H](Cc1cnc2ncccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)[O-])N(C)C(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)[O-])C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)(C)C)C1CCCCC1)C(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]
InChI	InChI=1S/C172H278N24O55.5Na/c1-9-10-11-12-13-14-15-16-17-18-19-20-27-44-146(202)182-136(170(226)227)53-56-144(200)177-64-67-229-69-71-231-73-75-233-77-79-235-81-83-237-85-87-239-89-91-241-93-95-243-97-99-245-101-103-247-105-107-249-109-111-251-113-112-250-110-108-248-106-104-246-102-100-244-98-96-242-94-92-240-90-88-238-86-84-236-82-80-234-78-76-232-74-72-230-70-68-228-66-59-145(201)175-60-31-29-41-135(169(224)225)186-165(220)152(126-37-25-22-26-38-126)193-162(217)142-43-34-65-196(142)168(223)140(116-125-47-51-129(199)52-48-125)190-157(212)133(54-57-148(204)205)184-161(216)139(117-127-120-180-154-130(127)39-32-62-178-154)188-159(214)138(115-124-45-49-128(198)50-46-124)189-166(221)153(172(5,6)7)194-163(218)143(119-150(208)209)195(8)167(222)141-118-147(203)176-61-30-28-40-131(181-122(4)197)158(213)192-151(121(2)3)164(219)185-134(55-58-149(206)207)156(211)183-132(42-33-63-179-171(173)174)155(210)187-137(160(215)191-141)114-123-35-23-21-24-36-123;;;;;/h21,23-24,32,35-36,39,45-52,62,120-121,126,131-143,151-153,198-199H,9-20,22,25-31,33-34,37-38,40-44,53-61,63-119H2,1-8H3,(H,175,201)(H,176,203)(H,177,200)(H,178,180)(H,181,197)(H,182,202)(H,183,211)(H,184,216)(H,185,219)(H,186,220)(H,187,210)(H,188,214)(H,189,221)(H,190,212)(H,191,215)(H,192,213)(H,193,217)(H,194,218)(H,204,205)(H,206,207)(H,208,209)(H,224,225)(H,226,227)(H4,173,174,179);;;;;/q;5*+1/p-4/t131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,151-,152-,153+;;;;;/m0...../s1
InChIKey	USORCWBBSVPUBL-TYSHKVMESA-J

Roles Classification

Biological Roles:

immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.

complement component 5 inhibitor Any inhibitor of complement component 5.

Application:

ChEBI Ontology

Outgoing Relation(s)
	zilucoplan sodium (CHEBI:229660) has part zilucoplan(4−) (CHEBI:229671)
	zilucoplan sodium (CHEBI:229660) has role complement component 5 inhibitor (CHEBI:229668)
	zilucoplan sodium (CHEBI:229660) has role immunosuppressive agent (CHEBI:35705)
	zilucoplan sodium (CHEBI:229660) is a organic sodium salt (CHEBI:38700)

Synonyms	Source
acetyl-[L-lysyl¹-L-valyl²-L-glutamyl³-L-arginyl⁴-L-phenylalanyl⁵-L-aspartyl⁶]-N-methyl-L-aspartyl⁷-L tert-leucyl⁸-L-tyrosyl⁹-L-7-azatryptophyl¹⁰-L-glutamyl¹¹-L-tyrosyl¹²-L-prolyl¹³-L-cyclohexylglycyl¹⁴-[L-lysyl¹⁵, Nε-palmitoyl-γ-L-glutamyl-(1-amino-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-tetracosaoxapentaheptacontan-75-oyl)], cyclic (lactam 1-6), tetra sodium	ChEBI
zilucoplan tetrasodium	ChEBI

Synonyms

Source

acetyl-[L-lysyl¹-L-valyl²-L-glutamyl³-L-arginyl⁴-L-phenylalanyl⁵-L-aspartyl⁶]-N-methyl-L-aspartyl⁷-L tert-leucyl⁸-L-tyrosyl⁹-L-7-azatryptophyl¹⁰-L-glutamyl¹¹-L-tyrosyl¹²-L-prolyl¹³-L-cyclohexylglycyl¹⁴-[L-lysyl¹⁵, Nε-palmitoyl-γ-L-glutamyl-(1-amino-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-tetracosaoxapentaheptacontan-75-oyl)], cyclic (lactam 1-6), tetra sodium

ChEBI

zilucoplan tetrasodium

ChEBI

Brand Name	Source
Zilbrysq	KEGG DRUG

Manual Xrefs	Databases
D12356	KEGG DRUG

Citations