sparsentan (CHEBI:229526)

CHEBI:229526 - sparsentan

ChEBI ID	CHEBI:229526
ChEBI Name	sparsentan
Stars
Definition	A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.
Last Modified	16 April 2024
Submitter	Adnan
Downloads	Molfile

Formula	C32H40N4O5S
Net Charge	0
Average Mass	592.762
Monoisotopic Mass	592.27194
SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
InChI	InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N

Wikipedia

Roles Classification

angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors.

endothelin A receptor antagonist A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.

angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors.

endothelin A receptor antagonist A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.

nephroprotective agent Any protective agent that is able to prevent damage to the kidney.

antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology

Outgoing Relation(s)
	sparsentan (CHEBI:229526) has role angiotensin receptor antagonist (CHEBI:61016)
	sparsentan (CHEBI:229526) has role antihypertensive agent (CHEBI:35674)
	sparsentan (CHEBI:229526) has role endothelin A receptor antagonist (CHEBI:51452)
	sparsentan (CHEBI:229526) has role nephroprotective agent (CHEBI:76595)
	sparsentan (CHEBI:229526) is a azaspiro compound (CHEBI:35624)
	sparsentan (CHEBI:229526) is a benzyl ether (CHEBI:59859)
	sparsentan (CHEBI:229526) is a biphenyls (CHEBI:22888)
	sparsentan (CHEBI:229526) is a isoxazoles (CHEBI:55373)
	sparsentan (CHEBI:229526) is a sulfonamide (CHEBI:35358)

IUPAC Name
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)[biphenyl]-2-sulfonamide

Synonyms	Source
PS-433540	DrugBank
PS433540	DrugBank
PS 433540	ChEBI
RE-021	DrugBank
2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide	ChEBI

Brand Name	Source
Filspari	KEGG DRUG

Citations