sparsentan (CHEBI:229526)

CHEBI:229526 - sparsentan

ChEBI ID	CHEBI:229526
ChEBI Name	sparsentan
Stars
Definition	A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.
Last Modified	16 April 2024
Submitter	Adnan
Downloads	Molfile

Formula	C32H40N4O5S
Net Charge	0
Average Mass	592.762
Monoisotopic Mass	592.27194
SMILES	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2noc(C)c2C)c(COCC)c1
InChI	InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N

Wikipedia

Roles Classification

angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors.

endothelin A receptor antagonist A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.

nephroprotective agent Any protective agent that is able to prevent damage to the kidney.

angiotensin receptor antagonist A hormone antagonist that blocks angiotensin receptors.

antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

endothelin A receptor antagonist A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.

ChEBI Ontology

Outgoing Relation(s)
	sparsentan (CHEBI:229526) has role angiotensin receptor antagonist (CHEBI:61016)
	sparsentan (CHEBI:229526) has role antihypertensive agent (CHEBI:35674)
	sparsentan (CHEBI:229526) has role endothelin A receptor antagonist (CHEBI:51452)
	sparsentan (CHEBI:229526) has role nephroprotective agent (CHEBI:76595)
	sparsentan (CHEBI:229526) is a azaspiro compound (CHEBI:35624)
	sparsentan (CHEBI:229526) is a benzyl ether (CHEBI:59859)
	sparsentan (CHEBI:229526) is a biphenyls (CHEBI:22888)
	sparsentan (CHEBI:229526) is a isoxazoles (CHEBI:55373)
	sparsentan (CHEBI:229526) is a sulfonamide (CHEBI:35358)

IUPAC Name
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)[biphenyl]-2-sulfonamide

Synonyms	Source
2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide	ChEBI
PS 433540	ChEBI
PS-433540	DrugBank
PS433540	DrugBank
RE-021	DrugBank

Brand Name	Source
Filspari	KEGG DRUG

Citations