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CHEBI:229236 - fezolinetant

ChEBI IDCHEBI:229236
ChEBI Namefezolinetant
Stars
DefinitionA triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause.
Last Modified16 April 2024
SubmitterAdnan
DownloadsMolfile
FormulaC16H15FN6OS
Net Charge0
Average Mass358.402
Monoisotopic Mass358.10121
SMILESCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1
InChIInChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
InChIKeyPPSNFPASKFYPMN-SECBINFHSA-N
Wikipedia
Roles Classification
Biological Role:
neurokinin-3 receptor antagonist  An antagonist at the neurokinin-3 receptor.
ChEBI Ontology
Outgoing Relation(s)
fezolinetant (CHEBI:229236) has role neurokinin-3 receptor antagonist (CHEBI:140482)
fezolinetant (CHEBI:229236) is a benzamides (CHEBI:22702)
fezolinetant (CHEBI:229236) is a monofluorobenzenes (CHEBI:83575)
fezolinetant (CHEBI:229236) is a tertiary carboxamide (CHEBI:140326)
fezolinetant (CHEBI:229236) is a thiadiazoles (CHEBI:38099)
fezolinetant (CHEBI:229236) is a triazolopyrazine (CHEBI:48277)
IUPAC Name 
(4-fluorophenyl)[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone
INNs  Source
fezolinetantumWHO MedNet
fézolinétantWHO MedNet
fezolinetantWHO MedNet
fezolinetantWHO MedNet
Synonyms  Source
ESN-364DrugBank
ESN364ChEBI
ESN 364DrugBank
Brand Name  Source
VeozahDrugBank
Manual XrefsDatabases
DB15669DrugBank
D11976KEGG DRUG
FezolinetantWikipedia
Registry NumbersSources
CAS:1629229-37-3KEGG DRUG
Citations