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CHEBI:228209 - KU-55933

Default Structure
ChEBI IDCHEBI:228209
ChEBI NameKU-55933
Stars
DefinitionA member of the class of thianthrenes that is thianthrene substituted by a 6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl group at position 1. It is potent inhibitor of ATM kinase.
Secondary ChEBI IDCHEBI:91372
Last Modified14 November 2023
SubmitterAdnan
DownloadsMolfile
FormulaC21H17NO3S2
Net Charge0
Average Mass395.505
Monoisotopic Mass395.06499
SMILESO=c1cc(-c2cccc3c2Sc2ccccc2S3)oc(N2CCOCC2)c1
InChIInChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChIKeyXRKYMMUGXMWDAO-UHFFFAOYSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
autophagy inducer  Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
radiosensitizing agent  A drug that makes increases the sensitivity of tumour cells to radiation therapy.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
KU-55933 (CHEBI:228209) has role antineoplastic agent (CHEBI:35610)
KU-55933 (CHEBI:228209) has role apoptosis inducer (CHEBI:68495)
KU-55933 (CHEBI:228209) has role autophagy inducer (CHEBI:138880)
KU-55933 (CHEBI:228209) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
KU-55933 (CHEBI:228209) has role neuroprotective agent (CHEBI:63726)
KU-55933 (CHEBI:228209) has role radiosensitizing agent (CHEBI:132992)
KU-55933 (CHEBI:228209) is a 4-pyranones (CHEBI:131906)
KU-55933 (CHEBI:228209) is a morpholines (CHEBI:38785)
KU-55933 (CHEBI:228209) is a thianthrenes (CHEBI:64513)
IUPAC Name 
2-(morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one
Synonyms  Source
2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-oneChEBI
2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranoneChEBI
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-oneChEBI
KU 55933ChEBI
KU55933ChEBI
Manual XrefsDatabases
LSM-1074LINCS
Registry NumbersSources
CAS:587871-26-9ChEBI
Citations