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CHEBI:228209 - KU-55933

ChEBI IDCHEBI:228209
ChEBI NameKU-55933
Stars
DefinitionA member of the class of thianthrenes that is thianthrene substituted by a 6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl group at position 1. It is potent inhibitor of ATM kinase.
Secondary ChEBI IDCHEBI:91372
Last Modified14 November 2023
SubmitterAdnan
DownloadsMolfile
FormulaC21H17NO3S2
Net Charge0
Average Mass395.505
Monoisotopic Mass395.06499
SMILESO=c1cc(-c2cccc3c2Sc2ccccc2S3)oc(N2CCOCC2)c1
InChIInChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChIKeyXRKYMMUGXMWDAO-UHFFFAOYSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
autophagy inducer  Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
radiosensitizing agent  A drug that makes increases the sensitivity of tumour cells to radiation therapy.
ChEBI Ontology
Outgoing Relation(s)
KU-55933 (CHEBI:228209) has role antineoplastic agent (CHEBI:35610)
KU-55933 (CHEBI:228209) has role apoptosis inducer (CHEBI:68495)
KU-55933 (CHEBI:228209) has role autophagy inducer (CHEBI:138880)
KU-55933 (CHEBI:228209) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
KU-55933 (CHEBI:228209) has role neuroprotective agent (CHEBI:63726)
KU-55933 (CHEBI:228209) has role radiosensitizing agent (CHEBI:132992)
KU-55933 (CHEBI:228209) is a 4-pyranones (CHEBI:131906)
KU-55933 (CHEBI:228209) is a morpholines (CHEBI:38785)
KU-55933 (CHEBI:228209) is a thianthrenes (CHEBI:64513)
IUPAC Name 
2-(morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one
Synonyms  Source
KU 55933ChEBI
KU55933ChEBI
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-oneChEBI
2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-oneChEBI
2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranoneChEBI
Manual XrefsDatabases
LSM-1074LINCS
Registry NumbersSources
CAS:587871-26-9ChEBI
Citations