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CHEBI:228145 - atglistatin

ChEBI IDCHEBI:228145
ChEBI Nameatglistatin
Stars
DefinitionA biphenyl that is 1,1'-biphenyl substituted by (dimethylcarbamoyl)amino and dimethylamino groups at positions 3 and 4', respectively. It is a potent inhibitor of adipose triglyceride lipase activity (IC50 = 700nM).
Last Modified9 April 2024
Submitterdoughowe
DownloadsMolfile
FormulaC17H21N3O
Net Charge0
Average Mass283.375
Monoisotopic Mass283.16846
SMILESCN(C)C(=O)Nc1cccc(-c2ccc(N(C)C)cc2)c1
InChIInChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
InChIKeyAWOPBSAJHCUSAS-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
EC 3.1.1.3 (triacylglycerol lipase) inhibitor  Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
Application:
cardioprotective agent  Any protective agent that is able to prevent damage to the heart.
ChEBI Ontology
Outgoing Relation(s)
atglistatin (CHEBI:228145) has role cardioprotective agent (CHEBI:77307)
atglistatin (CHEBI:228145) has role EC 3.1.1.3 (triacylglycerol lipase) inhibitor (CHEBI:65001)
atglistatin (CHEBI:228145) is a aromatic amine (CHEBI:33860)
atglistatin (CHEBI:228145) is a biphenyls (CHEBI:22888)
atglistatin (CHEBI:228145) is a tertiary amino compound (CHEBI:50996)
atglistatin (CHEBI:228145) is a ureas (CHEBI:47857)
IUPAC Name 
3-[4'-(dimethylamino)[biphenyl]-3-yl]-1,1-dimethylurea
Synonym  Source
N'-[4'-(dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylureaIUPAC
Manual XrefsDatabases
HMDB0248698HMDB
Registry NumbersSources
CAS:1469924-27-3ChEBI
Citations