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CHEBI:197440 - Recombinant Tumor Necrosis Factor-alpha (human)
| ChEBI ID | CHEBI:197440 |
| ChEBI Name | Recombinant Tumor Necrosis Factor-alpha (human) |
| Stars | |
| Definition | TNF-alpha is released from macrophages, monocytes, neutrophils, T-cells (principally CD4+), NK-cells and many transformed cell lines. Soluble homotrimeric TNF-alpha released from cells by proteolysis of the integral membrane precursor form of TNF-alpha. TNF-alpha binding to some TNF-alpha receptors induces apoptosis and depending on cell type, receptor expression, and signal transduction status can induce other responses. TNF-a is involved in the inflammatory response. |
| Submitter | jonmuyskens |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| Recombinant Tumor Necrosis Factor-alpha (human) (CHEBI:197440) is a organic molecular entity (CHEBI:50860) |
| Synonyms | Source |
|---|---|
| Cachectin | SUBMITTER |
| Differentiation inducing factor (DIF) | SUBMITTER |
| Macrophage cytotoxic factor (MCF) | SUBMITTER |
| Necrosin | SUBMITTER |
| TNFSF2 | SUBMITTER |
| Tumor necrosis factor-alpha | SUBMITTER |