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CHEBI:195559 - poziotinib

ChEBI IDCHEBI:195559
ChEBI Namepoziotinib
Stars
DefinitionA member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, [1-(prop-2-enoyl)piperidin-4-yl]oxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a potent and irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.
Last Modified18 August 2023
SubmitterAdnan
DownloadsMolfile
FormulaC23H21Cl2FN4O3
Net Charge0
Average Mass491.350
Monoisotopic Mass490.09747
SMILESC=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1
InChIInChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
InChIKeyLPFWVDIFUFFKJU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
epidermal growth factor receptor antagonist  An antagonist at the epidermal growth factor receptor.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
poziotinib (CHEBI:195559) has role antineoplastic agent (CHEBI:35610)
poziotinib (CHEBI:195559) has role apoptosis inducer (CHEBI:68495)
poziotinib (CHEBI:195559) has role epidermal growth factor receptor antagonist (CHEBI:74440)
poziotinib (CHEBI:195559) is a N-acylpiperidine (CHEBI:48591)
poziotinib (CHEBI:195559) is a acrylamides (CHEBI:22216)
poziotinib (CHEBI:195559) is a aromatic ether (CHEBI:35618)
poziotinib (CHEBI:195559) is a dichlorobenzene (CHEBI:23697)
poziotinib (CHEBI:195559) is a diether (CHEBI:46786)
poziotinib (CHEBI:195559) is a monofluorobenzenes (CHEBI:83575)
poziotinib (CHEBI:195559) is a quinazolines (CHEBI:38530)
poziotinib (CHEBI:195559) is a secondary amino compound (CHEBI:50995)
poziotinib (CHEBI:195559) is a substituted aniline (CHEBI:48975)
IUPAC Name 
1-(4-{[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one
INNs  Source
poziotinibWHO MedNet
poziotinibWHO MedNet
poziotinibWHO MedNet
poziotinibumWHO MedNet
Synonyms  Source
NOV120101ChEBI
HM781-36BChEBI
HM-781-36BDrugBank
HM 781-36BDrugBank
NOV-120101ChEBI
NOV 120101ChEBI
Manual XrefsDatabases
DB12114DrugBank
D12229KEGG DRUG
PoziotinibWikipedia
30687714ChemSpider
Registry NumbersSources
CAS:1092364-38-9DrugBank
Citations