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CHEBI:195522 - KuFal194

ChEBI IDCHEBI:195522
ChEBI NameKuFal194
Stars
DefinitionAn indoloquinoline that is 11H-indolo[3,2-c]quinoline substituted by carboxy and iodo groups at positions 6 and 10, respectively. It is a potent inhibitor of DYRK1A (IC50 = 6 nM).
Last Modified3 August 2023
Submitterdoughowe
DownloadsMolfile
FormulaC16H9IN2O2
Net Charge0
Average Mass388.164
Monoisotopic Mass387.97088
SMILESO=C(O)c1nc2ccccc2c2nc3c(I)cccc3c12
InChIInChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12-14(19-13(9)10)8-4-1-2-7-11(8)18-15(12)16(20)21/h1-7,19H,(H,20,21)
InChIKeySDRAETFVRBBLOB-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
EC 2.7.12.1 (dual-specificity kinase) inhibitor  An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of dual-specificity kinase (EC 2.7.12.1).
ChEBI Ontology
Outgoing Relation(s)
KuFal194 (CHEBI:195522) has role EC 2.7.12.1 (dual-specificity kinase) inhibitor (CHEBI:195525)
KuFal194 (CHEBI:195522) is a indoloquinoline (CHEBI:195524)
KuFal194 (CHEBI:195522) is a monocarboxylic acid (CHEBI:25384)
KuFal194 (CHEBI:195522) is a organoiodine compound (CHEBI:37142)
IUPAC Name 
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid
Synonyms  Source
KuFal-194ChEBI
KuFal 194ChEBI
Dyrk1A-IN-5ChEBI
Manual XrefsDatabases
4E1PDBeChem
Registry NumbersSources
CAS:1685235-41-9ChEBI
Citations