satavaptan (CHEBI:194402)

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CHEBI:194402 - satavaptan

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ChEBI ID	CHEBI:194402
ChEBI Name	satavaptan
Stars
Definition	A vasopressin V2 receptor antagonist that has been shown to improve hyponatremia in patients with cirrhosis, congestive heart failure, and syndrome of inappropriate antidiuresis.
Last Modified	20 February 2023
Submitter	slaulederkind
Downloads	Molfile

Formula	C33H45N3O8S
Net Charge	0
Average Mass	643.803
Monoisotopic Mass	643.29274
SMILES	CCOc1ccc2c(c1)[C@]1(CC[C@H](OCCN3CCOCC3)CC1)C(=O)N2S(=O)(=O)c1ccc(C(=O)NC(C)(C)C)cc1OC
InChI	InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+
InChIKey	QKXJWFOKVQWEDZ-VCCCEUOBSA-N

Wikipedia

Roles Classification

Biological Role:	vasopressin receptor antagonist Any drug which blocks vasopressin receptors.
Applications:	aquaretic A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss). vasopressin receptor antagonist Any drug which blocks vasopressin receptors.

ChEBI Ontology

Outgoing Relation(s)
	satavaptan (CHEBI:194402) has role aquaretic (CHEBI:194423)
	satavaptan (CHEBI:194402) has role vasopressin receptor antagonist (CHEBI:59680)
	satavaptan (CHEBI:194402) is a aromatic ether (CHEBI:35618)
	satavaptan (CHEBI:194402) is a benzamides (CHEBI:22702)
	satavaptan (CHEBI:194402) is a monomethoxybenzene (CHEBI:25235)
	satavaptan (CHEBI:194402) is a morpholines (CHEBI:38785)
	satavaptan (CHEBI:194402) is a oxaspiro compound (CHEBI:37948)
	satavaptan (CHEBI:194402) is a secondary carboxamide (CHEBI:140325)
	satavaptan (CHEBI:194402) is a sulfonamide (CHEBI:35358)

IUPAC Name
N-tert-butyl-4-[5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indole]-1'-yl]sulfonyl-3-methoxybenzamide

INNs	Source
satavaptan	WHO MedNet
satavaptanum	WHO MedNet
satavaptán	WHO MedNet
satavaptan	WHO MedNet

Synonyms	Source
SR121463	SUBMITTER
SR-121463	SUBMITTER
SR 121463	ChEBI

Brand Name	Source
Aquilda	ChEBI

Manual Xrefs	Databases
DB14923	DrugBank
HMDB0257503	HMDB
Satavaptan	Wikipedia

Registry Numbers	Sources
CAS:185913-78-4	DrugBank

Citations