EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:194147 - aristolochic acids

ChEBI IDCHEBI:194147
ChEBI Namearistolochic acids
Stars
DefinitionOrganic heterotetracyclic compounds which are a group of nitro phenanthrene organic acids, naturally found in many kinds of plants, such as Aristolochia and Asarum, and widely cultivated in Asia.They are identified as a class 1 human carcinogen by the International Agency for Research on Cancer owing to their carcinogenicity and nephrotoxicity and can pose a significant hazard to food safety and human health.
Last Modified5 December 2022
SubmitterMarcus Ennis
DownloadsMolfile
FormulaC16H6NO6
Net Charge0
Average Mass (excl. R groups)308.223
Monoisotopic Mass (excl. R groups)308.01951
SMILES[1*]c1cc2c(cc([N+](=O)[O-])c3c(C(=O)O)cc4c(c32)OCO4)c([3*])c1[2*]
Wikipedia
Species of MetaboliteComponentSourceComments
Aristolochia (ncbitaxon:12947) - PubMed (21141875)
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
carcinogenic agent  A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
nephrotoxin  A toxin that is produced by a biological organism such as a microbe, animal or plant which interferes with the function of the kidney in animals.
ChEBI Ontology
Outgoing Relation(s)
aristolochic acids (CHEBI:194147) has role carcinogenic agent (CHEBI:50903)
aristolochic acids (CHEBI:194147) has role nephrotoxin (CHEBI:61015)
aristolochic acids (CHEBI:194147) is a C-nitro compound (CHEBI:35716)
aristolochic acids (CHEBI:194147) is a cyclic acetal (CHEBI:59770)
aristolochic acids (CHEBI:194147) is a monocarboxylic acid (CHEBI:25384)
aristolochic acids (CHEBI:194147) is a organic heterotetracyclic compound (CHEBI:38163)
Incoming Relation(s)
aristolochic acid A (CHEBI:2825) is a aristolochic acids (CHEBI:194147)
aristolochic acid B (CHEBI:194149) is a aristolochic acids (CHEBI:194147)
aristolochic acid C (CHEBI:194151) is a aristolochic acids (CHEBI:194147)
aristolochic acid D (CHEBI:194152) is a aristolochic acids (CHEBI:194147)
Manual XrefsDatabases
Aristolochic acidWikipedia
Citations