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CHEBI:192545 - LY 379268

Default Structure
ChEBI IDCHEBI:192545
ChEBI NameLY 379268
Stars
DefinitionAn organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.
Last Modified6 July 2022
SubmitterKalpana P
DownloadsMolfile
FormulaC7H9NO5
Net Charge0
Average Mass187.151
Monoisotopic Mass187.04807
SMILES[H][C@@]12[C@@H](C(=O)O)[C@]1([H])OC[C@@]2(N)C(=O)O
InChIInChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
InChIKeyYASVRZWVUGJELU-MDASVERJSA-N
Wikipedia
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
metabotropic glutamate receptor agonist  An agonist that selectively binds to and activates a metabotropic glutamate receptor.
Applications:
antipsychotic agent  Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
ChEBI Ontology
Outgoing Relation(s)
LY 379268 (CHEBI:192545) has role antipsychotic agent (CHEBI:35476)
LY 379268 (CHEBI:192545) has role anxiolytic drug (CHEBI:35474)
LY 379268 (CHEBI:192545) has role metabotropic glutamate receptor agonist (CHEBI:61966)
LY 379268 (CHEBI:192545) has role neuroprotective agent (CHEBI:63726)
LY 379268 (CHEBI:192545) is a amino dicarboxylic acid (CHEBI:36164)
LY 379268 (CHEBI:192545) is a bridged compound (CHEBI:35990)
LY 379268 (CHEBI:192545) is a organic heterobicyclic compound (CHEBI:27171)
IUPAC Name 
(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Synonyms  Source
LY-379,268ChEBI
LY-379268ChEBI
LY379268ChEBI
Manual XrefsDatabases
LY-379,268Wikipedia
Registry NumbersSources
CAS:191471-52-0ChEBI
Citations