EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:192545 - LY 379268

Default Structure
ChEBI IDCHEBI:192545
ChEBI NameLY 379268
Stars
DefinitionAn organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.
Last Modified6 July 2022
SubmitterKalpana P
DownloadsMolfile
FormulaC7H9NO5
Net Charge0
Average Mass187.151
Monoisotopic Mass187.04807
SMILES[H][C@@]12[C@@H](C(=O)O)[C@]1([H])OC[C@@]2(N)C(=O)O
InChIInChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
InChIKeyYASVRZWVUGJELU-MDASVERJSA-N
Wikipedia
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
metabotropic glutamate receptor agonist  An agonist that selectively binds to and activates a metabotropic glutamate receptor.
Applications:
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
antipsychotic agent  Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
LY 379268 (CHEBI:192545) has role antipsychotic agent (CHEBI:35476)
LY 379268 (CHEBI:192545) has role anxiolytic drug (CHEBI:35474)
LY 379268 (CHEBI:192545) has role metabotropic glutamate receptor agonist (CHEBI:61966)
LY 379268 (CHEBI:192545) has role neuroprotective agent (CHEBI:63726)
LY 379268 (CHEBI:192545) is a amino dicarboxylic acid (CHEBI:36164)
LY 379268 (CHEBI:192545) is a bridged compound (CHEBI:35990)
LY 379268 (CHEBI:192545) is a organic heterobicyclic compound (CHEBI:27171)
IUPAC Name 
(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Synonyms  Source
LY-379,268ChEBI
LY-379268ChEBI
LY379268ChEBI
Manual XrefsDatabases
LY-379,268Wikipedia
Registry NumbersSources
CAS:191471-52-0ChEBI
Citations