LY-367,265 (CHEBI:183634)

EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:183634 - LY-367,265

Take structure to advanced search

ChEBI ID	CHEBI:183634
ChEBI Name	LY-367,265
Stars
Definition	A fluoroindole that is 1H-indole in which the hydrogens at positions 3 and 6 are replaced by 1-[2-(2,2-dioxo-5,6-dihydro-4H-2λ⁶-[1,2,5]thiadiazolo[4,3,2-ij]quinolin-1(2H)-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl and fluoro groups, respectively. It is an inhibitor of the 5-hydroxytryptamine transporter (Ki = 2.3 nM) and an antagonist of 5-hydroxytryptamine(2A) receptor (Ki = 0.81 nM).
Last Modified	9 November 2021
Submitter	Adnan
Downloads	Molfile

Formula	C24H25FN4O2S
Net Charge	0
Average Mass	452.555
Monoisotopic Mass	452.16823
SMILES	O=S1(=O)N(CCN2CC=C(c3cnc4cc(F)ccc34)CC2)c2cccc3c2N1CCC3
InChI	InChI=1S/C24H25FN4O2S/c25-19-6-7-20-21(16-26-22(20)15-19)17-8-11-27(12-9-17)13-14-28-23-5-1-3-18-4-2-10-29(24(18)23)32(28,30)31/h1,3,5-8,15-16,26H,2,4,9-14H2
InChIKey	BJIPVHLRWSDKOS-UHFFFAOYSA-N

Wikipedia

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:	serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology

Outgoing Relation(s)
	LY-367,265 (CHEBI:183634) has role antidepressant (CHEBI:35469)
	LY-367,265 (CHEBI:183634) has role geroprotector (CHEBI:176497)
	LY-367,265 (CHEBI:183634) has role serotonergic antagonist (CHEBI:48279)
	LY-367,265 (CHEBI:183634) has role serotonin uptake inhibitor (CHEBI:50949)
	LY-367,265 (CHEBI:183634) is a dihydropyridine (CHEBI:50075)
	LY-367,265 (CHEBI:183634) is a fluoroindole (CHEBI:131960)
	LY-367,265 (CHEBI:183634) is a tertiary amino compound (CHEBI:50996)
	LY-367,265 (CHEBI:183634) is a thiadiazoloquinoline (CHEBI:183635)

IUPAC Name
1-{2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]ethyl}-5,6-dihydro-1H,4H-[1,2,5]thiadiazolo[4,3,2-ij]quinoline 2,2-dioxide

Synonyms	Source
1-{2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-yl]ethyl}-5,6-dihydro-4H-2λ⁶-[1,2,5]thiadiazolo[4,3,2-ij]quinoline-2,2(1H)-dione	IUPAC
LY 367265	ChemIDplus
LY-367265	ChEBI
LY367265	ChemIDplus

Manual Xrefs	Databases
3797242	ChemSpider
LY-367,265	Wikipedia

Registry Numbers	Sources
CAS:210751-39-6	ChemIDplus

Citations