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CHEBI:180480 - amperozide

Default Structure
ChEBI IDCHEBI:180480
ChEBI Nameamperozide
Stars
DefinitionA member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs.
Secondary ChEBI IDCHEBI:92913
Last Modified20 September 2021
SubmitterAdnan
DownloadsMolfile
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
dopamine uptake inhibitor  A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
anxiolytic drug  Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
dopamine uptake inhibitor  A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
second generation antipsychotic  Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
ChEBI Ontology
Outgoing Relation(s)
amperozide (CHEBI:180480) has role anxiolytic drug (CHEBI:35474)
amperozide (CHEBI:180480) has role dopamine uptake inhibitor (CHEBI:51039)
amperozide (CHEBI:180480) has role geroprotector (CHEBI:176497)
amperozide (CHEBI:180480) has role second generation antipsychotic (CHEBI:65191)
amperozide (CHEBI:180480) has role serotonergic antagonist (CHEBI:48279)
amperozide (CHEBI:180480) is a N-alkylpiperazine (CHEBI:46845)
amperozide (CHEBI:180480) is a diarylmethane (CHEBI:51614)
amperozide (CHEBI:180480) is a monofluorobenzenes (CHEBI:83575)
amperozide (CHEBI:180480) is a secondary carboxamide (CHEBI:140325)
amperozide (CHEBI:180480) is a ureas (CHEBI:47857)
amperozide (CHEBI:180480) is conjugate base of amperozide(1+) (CHEBI:180484)
Incoming Relation(s)
amperozide(1+) (CHEBI:180484) is conjugate acid of amperozide (CHEBI:180480)
IUPAC Name 
4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
INNs  Source
amperozidaWHO MedNet
amperozideWHO MedNet
ampérozideWHO MedNet
amperozidumWHO MedNet
Synonym  Source
4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamideChemIDplus
Manual XrefsDatabases
193DrugCentral
66062ChemSpider
AmperozideWikipedia
DB08927DrugBank
EP0517787Patent
HMDB0248358HMDB
LSM-3159LINCS
WO9112805Patent
Registry NumbersSources
CAS:75558-90-6ChemIDplus
Citations