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CHEBI:177387 - brequinar
| Formula | C23H15F2NO2 |
| Net Charge | 0 |
| Average Mass | 375.374 |
| Monoisotopic Mass | 375.10709 |
| SMILES | Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O |
| InChI | InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28) |
| InChIKey | PHEZJEYUWHETKO-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2. antimetabolite A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. antiviral agent A substance that destroys or inhibits replication of viruses. anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. pyrimidine synthesis inhibitor A pathway inhibitor that inhibits the synthesis of pyrimidine. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| brequinar (CHEBI:177387) has role anticoronaviral agent (CHEBI:149553) |
| brequinar (CHEBI:177387) has role antimetabolite (CHEBI:35221) |
| brequinar (CHEBI:177387) has role antineoplastic agent (CHEBI:35610) |
| brequinar (CHEBI:177387) has role antiviral agent (CHEBI:22587) |
| brequinar (CHEBI:177387) has role EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor (CHEBI:77103) |
| brequinar (CHEBI:177387) has role immunosuppressive agent (CHEBI:35705) |
| brequinar (CHEBI:177387) has role pyrimidine synthesis inhibitor (CHEBI:68543) |
| brequinar (CHEBI:177387) is a biphenyls (CHEBI:22888) |
| brequinar (CHEBI:177387) is a monocarboxylic acid (CHEBI:25384) |
| brequinar (CHEBI:177387) is a monofluorobenzenes (CHEBI:83575) |
| brequinar (CHEBI:177387) is a quinolinemonocarboxylic acid (CHEBI:26512) |
| brequinar (CHEBI:177387) is conjugate acid of brequinar(1−) (CHEBI:177870) |
| Incoming Relation(s) |
| brequinar(1−) (CHEBI:177870) is conjugate base of brequinar (CHEBI:177387) |
| IUPAC Name |
|---|
| 6-fluoro-2-(2'-fluoro[biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid |
| INNs | Source |
|---|---|
| brequinar | WHO MedNet |
| bréquinar | WHO MedNet |
| brequinarum | WHO MedNet |
| brequinar | WHO MedNet |
| Synonyms | Source |
|---|---|
| 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid | PDBeChem |
| 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid | PDBeChem |
| 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid | SUBMITTER |
| biphenquinate | SUBMITTER |
| 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid | IUPAC |
| 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid | PDBeChem |
| Citations |
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