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CHEBI:177387 - brequinar
| Formula | C23H15F2NO2 |
| Net Charge | 0 |
| Average Mass | 375.374 |
| Monoisotopic Mass | 375.10709 |
| SMILES | Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O |
| InChI | InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28) |
| InChIKey | PHEZJEYUWHETKO-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. pyrimidine synthesis inhibitor A pathway inhibitor that inhibits the synthesis of pyrimidine. antimetabolite A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2. antiviral agent A substance that destroys or inhibits replication of viruses. |
| Applications: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| brequinar (CHEBI:177387) has role anticoronaviral agent (CHEBI:149553) |
| brequinar (CHEBI:177387) has role antimetabolite (CHEBI:35221) |
| brequinar (CHEBI:177387) has role antineoplastic agent (CHEBI:35610) |
| brequinar (CHEBI:177387) has role antiviral agent (CHEBI:22587) |
| brequinar (CHEBI:177387) has role EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor (CHEBI:77103) |
| brequinar (CHEBI:177387) has role immunosuppressive agent (CHEBI:35705) |
| brequinar (CHEBI:177387) has role pyrimidine synthesis inhibitor (CHEBI:68543) |
| brequinar (CHEBI:177387) is a biphenyls (CHEBI:22888) |
| brequinar (CHEBI:177387) is a monocarboxylic acid (CHEBI:25384) |
| brequinar (CHEBI:177387) is a monofluorobenzenes (CHEBI:83575) |
| brequinar (CHEBI:177387) is a quinolinemonocarboxylic acid (CHEBI:26512) |
| brequinar (CHEBI:177387) is conjugate acid of brequinar(1−) (CHEBI:177870) |
| Incoming Relation(s) |
| brequinar(1−) (CHEBI:177870) is conjugate base of brequinar (CHEBI:177387) |
| IUPAC Name |
|---|
| 6-fluoro-2-(2'-fluoro[biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid |
| INNs | Source |
|---|---|
| brequinar | WHO MedNet |
| brequinar | WHO MedNet |
| bréquinar | WHO MedNet |
| brequinarum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid | PDBeChem |
| 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid | IUPAC |
| 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid | PDBeChem |
| 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid | PDBeChem |
| 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid | SUBMITTER |
| biphenquinate | SUBMITTER |
| Citations |
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