L-817818 (CHEBI:177199)

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CHEBI:177199 - L-817818

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ChEBI ID	CHEBI:177199
ChEBI Name	L-817818
Stars
Definition	A benzoindole that is 1H-benzo[g]indole substituted by naphthalen-2-yl and 2-({(2R)-6-amino-1-[(2S)-2-aminopropoxy]-1-oxohexan-2-yl}amino)-2-oxoethyl groups at positions 2 and 3, respectively. It is a selective nonpeptidic agonist of the somatostatin subtype-5 (SST₅) receptor with K_i of 0.4 nM.
Last Modified	5 August 2021
Submitter	Sandra Orchard
Downloads	Molfile

Formula	C33H36N4O3
Net Charge	0
Average Mass	536.676
Monoisotopic Mass	536.27874
SMILES	C[C@H](N)COC(=O)[C@@H](CCCCN)NC(=O)Cc1c(-c2ccc3ccccc3c2)nc2c1ccc1ccccc12
InChI	InChI=1S/C33H36N4O3/c1-21(35)20-40-33(39)29(12-6-7-17-34)36-30(38)19-28-27-16-15-23-9-4-5-11-26(23)32(27)37-31(28)25-14-13-22-8-2-3-10-24(22)18-25/h2-5,8-11,13-16,18,21,29,37H,6-7,12,17,19-20,34-35H2,1H3,(H,36,38)/t21-,29+/m0/s1
InChIKey	NFVRGDRCCNEGBS-KCWXNJEJSA-N

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:	somatostatin receptor agonist An agonist that binds to and activates somatostatin receptors.
Applications:	hypoglycemic agent A drug which lowers the blood glucose level. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders.

ChEBI Ontology

Outgoing Relation(s)
	L-817818 (CHEBI:177199) has role hypoglycemic agent (CHEBI:35526)
	L-817818 (CHEBI:177199) has role neuroprotective agent (CHEBI:63726)
	L-817818 (CHEBI:177199) has role somatostatin receptor agonist (CHEBI:177023)
	L-817818 (CHEBI:177199) is a benzoindole (CHEBI:38111)
	L-817818 (CHEBI:177199) is a carboxylic ester (CHEBI:33308)
	L-817818 (CHEBI:177199) is a naphthalenes (CHEBI:25477)
	L-817818 (CHEBI:177199) is a primary amino compound (CHEBI:50994)
	L-817818 (CHEBI:177199) is a secondary carboxamide (CHEBI:140325)

IUPAC Name
(2S)-2-aminopropyl N²-{[2-(naphthalen-2-yl)-1H-benzo[g]indol-3-yl]acetyl}-D-lysinate

Synonyms	Source
(2S)-2-aminopropyl (2R)-6-amino-2-{2-[2-(naphthalen-2-yl)-1H-benzo[g]indol-3-yl]acetamido}hexanoate	IUPAC
L-817,818	ChEBI
L 817818	ChEBI
L817818	ChEBI

Manual Xrefs	Databases
8112641	ChemSpider

Registry Numbers	Sources
CAS:217480-27-8	SUBMITTER

Citations