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CHEBI:176788 - dizocilpine maleate

Default Structure
ChEBI IDCHEBI:176788
ChEBI Namedizocilpine maleate
Stars
DefinitionA maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.
Last Modified9 July 2021
SubmitterAdnan
DownloadsMolfile
FormulaC16H15N.C4H4O4
Net Charge0
Average Mass337.375
Monoisotopic Mass337.13141
SMILESO=C(O)/C=C\C(=O)O.[H][C@]12Cc3ccccc3[C@](C)(N1)c1ccccc12
InChIInChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
InChIKeyQLTXKCWMEZIHBJ-PJGJYSAQSA-N
Roles Classification
Biological Roles:
nicotinic antagonist  An antagonist at the nicotinic cholinergic receptor.
NMDA receptor antagonist  Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Applications:
anticonvulsant  A drug used to prevent seizures or reduce their severity.
nicotinic antagonist  An antagonist at the nicotinic cholinergic receptor.
anaesthetic  Substance which produces loss of feeling or sensation.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
dizocilpine maleate (CHEBI:176788) has part dizocilpine(1+) (CHEBI:176787)
dizocilpine maleate (CHEBI:176788) has role anaesthetic (CHEBI:38867)
dizocilpine maleate (CHEBI:176788) has role anticonvulsant (CHEBI:35623)
dizocilpine maleate (CHEBI:176788) has role neuroprotective agent (CHEBI:63726)
dizocilpine maleate (CHEBI:176788) has role nicotinic antagonist (CHEBI:48878)
dizocilpine maleate (CHEBI:176788) has role NMDA receptor antagonist (CHEBI:60643)
dizocilpine maleate (CHEBI:176788) is a maleate salt (CHEBI:50221)
dizocilpine maleate (CHEBI:176788) is a tetracyclic antidepressant (CHEBI:50940)
IUPAC Name 
(5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
Synonyms  Source
Dizocilpine maleateChEMBL
MK 801ChemIDplus
MK-801ChemIDplus
Manual XrefsDatabases
D03878KEGG DRUG
Registry NumbersSources
CAS:77086-22-7ChemIDplus
Citations