EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:173097 - liproxstatin-1

ChEBI IDCHEBI:173097
ChEBI Nameliproxstatin-1
Stars
DefinitionAn azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.
Last Modified27 May 2021
SubmitterAdnan
DownloadsMolfile
FormulaC19H21ClN4
Net Charge0
Average Mass340.858
Monoisotopic Mass340.14547
SMILESClc1cccc(CNC2=Nc3ccccc3NC23CCNCC3)c1
InChIInChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChIKeyYAFQFNOUYXZVPZ-UHFFFAOYSA-N
Roles Classification
Chemical Roles:
radical scavenger  A role played by a substance that can react readily with, and thereby eliminate, radicals.
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Role:
ferroptosis inhibitor  Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Application:
cardioprotective agent  Any protective agent that is able to prevent damage to the heart.
ChEBI Ontology
Outgoing Relation(s)
liproxstatin-1 (CHEBI:173097) has role antioxidant (CHEBI:22586)
liproxstatin-1 (CHEBI:173097) has role cardioprotective agent (CHEBI:77307)
liproxstatin-1 (CHEBI:173097) has role ferroptosis inhibitor (CHEBI:173084)
liproxstatin-1 (CHEBI:173097) has role radical scavenger (CHEBI:48578)
liproxstatin-1 (CHEBI:173097) is a azaspiro compound (CHEBI:35624)
liproxstatin-1 (CHEBI:173097) is a monochlorobenzenes (CHEBI:83403)
liproxstatin-1 (CHEBI:173097) is a organic heterotricyclic compound (CHEBI:26979)
liproxstatin-1 (CHEBI:173097) is a secondary amino compound (CHEBI:50995)
IUPAC Name 
N-(3-chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
Synonyms  Source
N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amineIUPAC
Lip-1ChEBI
liproxstatin 1ChEBI
liproxstatin1ChEBI
Manual XrefsDatabases
20387119ChemSpider
Registry NumbersSources
CAS:950455-15-9ChEBI
Citations