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CHEBI:167659 - GDC-0623

ChEBI IDCHEBI:167659
ChEBI NameGDC-0623
Stars
DefinitionA member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.
Last Modified17 March 2021
SubmitterR. Stephan
DownloadsMolfile
FormulaC16H14FIN4O3
Net Charge0
Average Mass456.215
Monoisotopic Mass456.00947
SMILESO=C(NOCCO)c1ccc2cncn2c1Nc1ccc(I)cc1F
InChIInChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
InChIKeyRFWVETIZUQEJEF-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor  An EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor that inhibits the action of mitogen-activated protein kinase kinase (EC 2.7.12.2).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
GDC-0623 (CHEBI:167659) has role antineoplastic agent (CHEBI:35610)
GDC-0623 (CHEBI:167659) has role apoptosis inducer (CHEBI:68495)
GDC-0623 (CHEBI:167659) has role EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor (CHEBI:88286)
GDC-0623 (CHEBI:167659) is a hydroxamic acid ester (CHEBI:75606)
GDC-0623 (CHEBI:167659) is a imidazopyridine (CHEBI:46908)
GDC-0623 (CHEBI:167659) is a monofluorobenzenes (CHEBI:83575)
GDC-0623 (CHEBI:167659) is a organoiodine compound (CHEBI:37142)
GDC-0623 (CHEBI:167659) is a primary alcohol (CHEBI:15734)
GDC-0623 (CHEBI:167659) is a secondary amino compound (CHEBI:50995)
GDC-0623 (CHEBI:167659) is a substituted aniline (CHEBI:48975)
IUPAC Name 
5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Synonyms  Source
GDC0623ChEBI
GDC 0623ChemIDplus
RG 7421ChemIDplus
5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamideChEBI
G-868ChEBI
G 868ChEBI
Manual XrefsDatabases
DB11982DrugBank
LCJPDBeChem
30687718ChemSpider
Registry NumbersSources
CAS:1168091-68-6ChemIDplus
Citations